| Fibrinogen Structural Changes Caused by Glass Surface Adsorption Detected by Solid Surface Fluorescence Spectroscopy |
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| 引用本文： | 公衍道,丁晓岚,杜培成,张秀芳,赵南明.Fibrinogen Structural Changes Caused by Glass Surface Adsorption Detected by Solid Surface Fluorescence Spectroscopy[J].清华大学学报,1997(1). |
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| 作者姓名： | 公衍道 丁晓岚 杜培成 张秀芳 赵南明 |
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| 作者单位： | Gong Yandao，Ding Xiaolan，Du Peicheng，Zhang Xiufang，Zhao Nanming ** Department of Biological Science and Biotechnology，State Key Laboratory of Biomembrane and Membrane Biotechnology，Tsinghua University，Beijing 100084 |
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| 摘 要： | ＦｉｂｒｉｎｏｇｅｎＳｔｒｕｃｔｕｒａｌＣｈａｎｇｅｓＣａｕｓｅｄｂｙＧｌａｓｓＳｕｒｆａｃｅＡｄｓｏｒｐｔｉｏｎＤｅｔｅｃｔｅｄｂｙＳｏｌｉｄＳｕｒｆａｃｅＦｌｕｏｒｅｓｃｅｎｃｅＳｐｅｃｔｒｏｓｃｏｐｙ＊ＧｏｎｇＹａｎｄａｏ（公衍道），ＤｉｎｇＸ...
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Fibrinogen Structural Changes Caused by Glass Surface Adsorption Detected by Solid Surface Fluorescence Spectroscopy * |
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| Gong Yandao,Ding Xiaolan,Du Peicheng,Zhang Xiufang,Zhao Nanming.Fibrinogen Structural Changes Caused by Glass Surface Adsorption Detected by Solid Surface Fluorescence Spectroscopy *[J].Tsinghua Science and Technology,1997(1). |
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| Authors: | Gong Yandao Ding Xiaolan Du Peicheng Zhang Xiufang Zhao Nanming |
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| Institution: | Gong Yandao,Ding Xiaolan,Du Peicheng,Zhang Xiufang,Zhao Nanming ** Department of Biological Science and Biotechnology,State Key Laboratory of Biomembrane and Membrane Biotechnology,Tsinghua University,Beijing 100084 |
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| Abstract: | Solid surface fluorescence (SSF) spectra of fibrinogen (FG) adsorbed on a glass surface were measured. For comparison, solution fluorescence (SF) spectra of native, thermally denatured, urea denatured FG solution with FG desorbed from a glass surface and the SSF spectra of native FG powder were recorded. To analyze the structural changes induced by the surface adsorption, all the aqueous samples mentioned above were analyzed by circular dichroism (CD) spectroscopy. The results demonstrated that the structural changes of FG induced by glass adsorption caused changes in the spectroscopic features of the SSF spectra, especially in the excitation (EX) spectra. It is suggested that SSF spectroscopy may be a useful tool for studying the structures of surface/interface biomolecules and for evaluating the biocompatibility of biomaterials. |
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| Keywords: | solid surface fluorescence (SSF) spectroscopy glass surface adsorption fibrinogen (FG) structure of surface/interface biomolecules |
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