Amino acid composition and sequence of crinia-angiotensin, an angiotensin II-like endecapeptide from the skin of the Australian frog Crinia georgiana. |
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Authors: | V Erspamer P Melchiorri T Nakajima T Yasuhara R Endean |
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Abstract: | Methanol extracts of the skin of the Australian amphibian Crinia georgiana contain large amounts of crinia-angiotensin II, a new angiotensin II-like peptide. This differs sharply from the conventional octapeptide angiotensins II in having attached the tripeptide Ala-Pro-Gly- to the N-terminus, and having an Ile residue substituted for the Val residue at position 6 from the C-terminus. Small amounts of angiotensin-like peptides have been traced, by radioimmunoassay, in skin extracts of some other Crinia species. |
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