| 全氟辛酸对小鼠肝脏相关酶系的影响 |
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| 引用本文： | 郎朗,宋大禹,季宇彬. 全氟辛酸对小鼠肝脏相关酶系的影响[J]. 北京联合大学学报(自然科学版), 2012, 26(3): 38-40 |
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| 作者姓名： | 郎朗 宋大禹 季宇彬 |
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| 作者单位： | 哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨,150076;哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨,150076;哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨,150076 |
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| 基金项目： | 黑龙江省青年骨干教师项目 |
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| 摘 要： | 目的:观察全氟辛酸对小鼠肝脏相关酶系的影响。方法:将小鼠随机分为4组,分别为空白组、1/16LD50、1/8LD50和1/4LD50组,染毒14 d后采用试剂盒法测定肝组织匀浆中琥珀酸脱氢酶(SDH)、血清中乳酸脱氢酶(LDH)和血清中单胺氧化酶(MAO)含量的变化。结果:染毒组肝组织中SDH活性显著低于空白组(P0.01),随染毒剂量增加呈递减趋势;染毒组血清中LDH和MAO活性显著高于空白组(P0.01)。随染毒剂量增加呈递增趋势。结论:全氟辛酸通过损伤肝细胞线粒体,破坏能量代谢,进而损伤肝组织,可致肝坏死。
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| 关 键 词： | 全氟辛酸(PFOA) 琥珀酸脱氢酶(SDH) 乳酸脱氢酶(LDH) 单胺氧化酶(MAO) |
Effects of PFOA on Relevant Enzymes Department in Liver of Mice |
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| LANG Lang,Song Da-yu,JI Yu-bin. Effects of PFOA on Relevant Enzymes Department in Liver of Mice[J]. Journal of Beijing Union University, 2012, 26(3): 38-40 |
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| Authors: | LANG Lang Song Da-yu JI Yu-bin |
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| Affiliation: | (Research Centre on Life Sciences and Environment Sciences,Harbin University of Commerce,Harbin 150076,China) |
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| Abstract: | AIM: To investigate the effects of PFOA on relevant enzymes department in liver of mice.Methods: Mice were divided into 4 groups randomly,the control group,1/16LD50,1/8LD50,1/4LD50.After exposure for 14d,succinate dehydrogenase(SDH),lactate dehydrogenase(LDH),Monoamine oxidase(MAO) were measured by the method of reagent’ s directions.Results: Activity of SDH in the model group were lower remarkably than those in the control group(P<0.01),and decreased in a dose-dependent way.Activity of LDH and MAO in the model group were higher remarkably than those in the control group(P<0.01),and increased in a dose-dependent way.Conclusion: PFOA induced liver injury by damaging Mitochondria and energy decompensation,finally caused liver necrosis. |
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| Keywords: | Perfluorooctanoic acid (PFOA) succinate dehydrogenase (SDH) lactate dehydrogenase ( LDH ) Monoamine oxidase (MAO) |
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