| 奥美拉唑核磁共振结构解析中化学交换对信号的影响 |
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| 引用本文： | 张巍,李敏一,欧阳捷,林文翰,邓志威.奥美拉唑核磁共振结构解析中化学交换对信号的影响[J].北京师范大学学报(自然科学版),2006,42(2):166-170. |
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| 作者姓名： | 张巍 李敏一 欧阳捷 林文翰 邓志威 |
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| 作者单位： | 北京师范大学分析测试中心,100875,北京;北京大学医学部天然药物及仿生药物国家重点实验室,100083,北京 |
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| 基金项目： | 国家“八六三”计划资助项目(2001AA620403) |
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| 摘 要： | 利用HSQC技术对2种溶剂体系下奥美拉唑(Omeprazole)分子中特定碳原子的横向弛豫时间T2进行了测定.测定结果显示2种不同溶剂体系下的T2值差别很大,证明了在DMSO-d6溶剂体系中该化合物存在一个分子内的化学交换过程.实验通过改变溶剂体系的手段抑制了化学交换现象,获得了理想的核磁谱图,并顺利地完成了奥美拉唑分子的结构确定,还对这一化学交换过程导致NMR信号异常的原因进行了探讨.
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| 关 键 词： | 核磁共振 横向弛豫时间 化学交换 |
| 收稿时间： | 2005-10-28 |
| 修稿时间： | 2005年10月28日 |
EFFECT OF CHEMICAL EXCHANGE ON NMR SIGNALS FOR STRUCTURE ANALYSIS OF OMEPRAZOLE |
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| Zhang Wei,Li Minyi,Ouyang Jie,Lin Wenhan,Deng Zhiwei.EFFECT OF CHEMICAL EXCHANGE ON NMR SIGNALS FOR STRUCTURE ANALYSIS OF OMEPRAZOLE[J].Journal of Beijing Normal University(Natural Science),2006,42(2):166-170. |
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| Authors: | Zhang Wei Li Minyi Ouyang Jie Lin Wenhan Deng Zhiwei |
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| Abstract: | With HSQC technique,the transverse relaxation time T_(2) was determined for certain carbon nuclear on the molecule of Omeprazole in two solvent systems.The results showed that the values of T_(2) were different in the two systems.Therefore,it could be confirmed that there was an intra-molecular chemical exchange as Omeprazole was dissolved in DMSO-d6.In this work,the chemical exchange was suppressed when a different solvent system was used.Thus,a set of ideal NMR spectrum were obtained and the molecular structure of Omeprazole was determined properly.The effect of the chemical exchange on NMR signals is discussed as well. |
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| Keywords: | NMR transverse relaxation time chemical exchange |
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