家庭氧疗对缓解期慢性阻塞性肺疾病的疗效分析

目的探讨家庭长期氧疗（LTOT）对慢性阻塞性肺疾病（COPD）患者的疗效。方法将我院同期住院病人随机分为治疗组和对照组各45人，治疗组患者定时供氧，给予15h／d以上的氧疗，应用压缩氧气、鼻导管给氧法，氧流量2L／min。两组治疗周期均为1年，对两组病人进行连续1年追踪随访，根据病情1-3个月随诊1次，全部患者治疗前后复查血气分析、肺功能。结果晚期COPD患者缓解期行长期LTOT，VC、FVC、FEV1明显改善，长期氧疗组治疗后动脉血氧分压水平上升，与治疗前比较，差异均有显著性意义，而且与对照组比较也有明显提高，差异有显著性，动脉血二氧化碳分压下降，与对照组差异显著性。结论合理使用LTOT可提高肺泡内氧分压，增加氧弥散能力，增加组织供氧，降低肺动脉压力，减轻呼吸困难程度，提高生活质量。

Therapeutic effect analysis of long-term domiciliary oxygen therapy to COPD in paracmasis

Objective: To study the therapeutic effect of long-term domiciliary oxygen therapy(LTDOT) on patients with chronic obstructive pulmonary disease(CODP) in paracmasis.Methods: 90 patients with CODP in paracmasis were randomly divided into two groups,the LTDOT group(n=45) and control group(n = 45).The LTDOT group was received persistent nasal catheter oxygen inspiration(2L/min,>15h/d).The follow up time was one year,and follow-up visit was performed every one or three months according to different condition of the patients.Blood gas analysis and the measurement of lung funcation of the pa-tients were performed before and after treatment.Results: Comparison between before and after oxygen therapy,the PaO2,VC,FVC,and FEV1 were significantly improved and PaCO2 were decreased in the LT-DOT group(P<0.05).Conclusions: LTDOT can maintain the PaO2 in high level,improve the lung function and the life quality of COPD patients.