The response of human skeletal muscle tissue to hypoxia |
| |
Authors: | Carsten Lundby Jose A L Calbet Paul Robach |
| |
Institution: | 1. The Copenhagen Muscle Research Centre, Rigshospitalet Sect. 7652, 2100, Copenhagen, Denmark 2. Department of Sport Science, University of ?rhus, 8200, ?rhus N, Denmark 3. Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain 4. Ecole Nationale de Ski et d’Alpinisme, 74401, Chamonix, France
|
| |
Abstract: | Hypoxia refers to environmental or clinical settings that potentially threaten tissue oxygen homeostasis. One unique aspect
of skeletal muscle is that, in addition to hypoxia, oxygen balance in this tissue may be further compromised when exercise
is superimposed on hypoxia. This review focuses on the cellular and molecular responses of human skeletal muscle to acute
and chronic hypoxia, with emphasis on physical exercise and training. Based on published work, it is suggested that hypoxia
does not appear to promote angiogenesis or to greatly alter oxidative enzymes in skeletal muscle at rest. Although the HIF-1
pathway in skeletal muscle is still poorly documented, emerging evidence suggests that muscle HIF-1 signaling is only activated
to a minor degree by hypoxia. On the other hand, combining hypoxia with exercise appears to improve some aspects of muscle
O2 transport and/or metabolism. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|