Applications of radiotracer techniques for the pharmacology and toxicology studies of nanomaterials |
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Authors: | ZhiYong Zhang YuLiang Zhao ZhiFang Chai |
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Institution: | (1) Key Laboratory of Nuclear Analytical Techniques, and Laboratory for Biological Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China |
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Abstract: | With the rapid development of nanosciences and nanotechnology, a wide variety of manufactured nanomaterials are now used in
commodities, pharmaceutics, cosmetics, biomedical products, and industries. While nanomaterials possess more novel and unique
physicochemical properties than bulk materials, they also have an unpredictable impact on human health. In the pharmacology
and toxicology studies of nanomaterials, it is essential to know the basic behavior in vivo, i.e. absorption, distribution, metabolism, and excretion (ADME) of these newly designed materials. Radiotracer techniques
are especially well suited to such studies and have got the chance to demonstrate their enchantment. In this paper, radiolabeling
methods for carbon nanomaterials, metallic and metal oxide nanoparticles, etc. are summarized and the applications of the
radiolabeled nanomaterials in pharmacology and toxicology studies are outlined.
Supported by the National Basic Research and Development Program of China (Grant Nos. 2006CB705605 and 2006CB932505), Chinese
Academy of Sciences (Grant No. KJCX3.SYW.N3), and National Natural Science Foundation of China (Grant Nos. 10525524, 10505024
and 20707027) |
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Keywords: | radiotracer nanoparticles toxicology pharmacology quantitative analysis biodistribution |
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