Regulation of nicotinic acetylcholine receptors by tyrosine kinases in the peripheral and central nervous system: same players, different roles |
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Authors: | A Wiesner C Fuhrer |
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Institution: | (1) Department of Neurochemistry, Brain Research Institute, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland |
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Abstract: | Nicotinic acetylcholine receptors (nAChRs) exist in many subtypes and are found in the peripheral and central nervous system
where they mediate or modulate synaptic transmission. We review how tyrosine phosphorylation and kinases regulate muscle and
neuronal nAChRs. Interestingly, although some of the same kinase players interact with the various receptor subtypes, the
functional consequences are different. While concerted action of MuSK, Abl- and Src-family kinases (SFKs) regulates the synaptic
distribution of nAChRs at the neuromuscular junction, SFKs activate heteromeric neuronal nAChRs in adrenal chromaffin cells,
thereby enhancing catecholamine secretion. In contrast, the activity of homomeric neuronal nAChRs, as found in the hippocampus,
is negatively regulated by tyrosine phosphorylation and SFKs. It appears that tyrosine kinases provide the means to regulate
all nAChRs; but the functional consequences, even those caused by the same kinase family, are specific for each receptor subtype
and location.
Received 21 February 2006; received after revision 24 July 2006; accepted 30 August 2006 |
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Keywords: | Nicotinic acetylcholine receptor neuromuscular junction chromaffin cells hippocampus tyrosine phosphorylation Src Abl MuSK |
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