Prolactin, growth hormone and the immune system in humans |
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Authors: | B Velkeniers Z Dogusan F Naessens R Hooghe E L Hooghe-Peters |
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Institution: | (1) Department of Pharmacology, Medical School, Free University of Brussels (VUB), B-1090 Brussels (Belgium), Fax +32 2 477 44 64, e-mail: ezhooghe@farc.vub.ac.be, BE;(2) Environmental Toxicology, Flemish Institute for Technological Research (VITO), B-2400 Mol (Belgium), BE |
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Abstract: | Prolactin (PRL) and growth hormone (GH) qualify as lymphoid growth and differentiation factors. Yet, long-standing hyper-
or hyposecretion of PRL or GH does not induce any significant alteration of the immune system. Subclinical changes in laboratory
parameters (such as chemotaxis or phagocytosis by granulocytes or macrophages or natural killer cell activity) have been reported
in some of these conditions. The GH-insulin-like growth factor (IGF)-I axis is dysregulated in ageing, in catabolic states
and in critical illness. Immune parameters, such as infection rate, are being monitored during clinical trials with GH or
IGF-I. Hyperprolactinaemia may play an aggravating role in systemic lupus erythematosus, in autoimmune thyroiditis and in
other autoimmune diseases. The patient may benefit from increased alertness about interactions between the endocrine and immune
systems. |
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Keywords: | , Prolactin, growth hormone, insulin-like growth factor, AIDS, ageing, pituitary adenoma, acromegaly, |
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