| 强电脉冲对抗癌药物毒性的提高作用 |
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| 引用本文： | 邹方东,岳碧松,王子淑,王保义.强电脉冲对抗癌药物毒性的提高作用[J].四川大学学报(自然科学版),2002,39(2):349-351. |
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| 作者姓名： | 邹方东 岳碧松 王子淑 王保义 |
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| 作者单位： | 四川大学生命科学学院,成都610064 |
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| 摘 要： | 研究了强电脉冲作用下，抗癌药物环磷酰胺对HeLa细胞和胎儿脐带血细胞的毒性变化。实验发现，当强电脉冲（电压500V，电容10μF， 脉冲5个） 结合环磷酰胺处理HeLa细胞后，细胞凋亡比例和死亡比例都比环磷酰胺单独处理组要高；当强电脉冲（电压1000V，电容10μF，脉冲2个）结合环磷酰胺处理胎儿脐带血细胞，发现染色体畸变和微核比例比单独药物处理组高。说明强电脉冲能明显提高抗癌药物对细胞的毒性。
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| 关 键 词： | 强电脉冲 抗癌药物 毒性 环磷酰胺 HeLa 细胞 胎儿脐带血细胞 肿瘤治疗 |
| 文章编号： | 0490-6756(2002)02-0349-03 |
Enhanced Cytotoxinic Effects of Cyclophosphamide by Highintensity Pulsing Electromagnetic Field |
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| ZOU Fang-dong,YUE Bi-song,WANG Zi-shu,WANG Bao-yi.Enhanced Cytotoxinic Effects of Cyclophosphamide by Highintensity Pulsing Electromagnetic Field[J].Journal of Sichuan University (Natural Science Edition),2002,39(2):349-351. |
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| Authors: | ZOU Fang-dong YUE Bi-song WANG Zi-shu WANG Bao-yi |
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| Abstract: | Cyclophosphamide,combined with or without high intensity pulsing electromagnetic field, was used as anti-cancer drug to treat HeLa cell and fetal navel cord blood cells. It was found that the drug's cytotoxicity to these two types of cells was enhanced after high intensity pulsing electromagnetic field was used together with the anti-cancer drug. The apoptosis and death percentage of HeLa cell, and the chromosome aberration and micronuleus percentage of fetal navel cord blood cells were higher than those of unexposed groups. |
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| Keywords: | high intensity pulsing electromagnetic field anti-caner drug cytotoxicity |
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