Comparative FTIR spectroscopic analysis of human breast benign and malignant tissues |
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Authors: | Yunxiang Ci Tiyu Gao Jun Feng Zhenquan Guo Xiu Kan Jiangqiang Dong |
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Institution: | (1) Department of Chemistry, Peking Uniccrsiry, 100871 Beijing, China;(2) Department of Biology, Peking Univiersity, 100871 Beijing, China;(3) Department of Pathology, Heijing Medical University, 100044 Beijing, China |
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Abstract: | Some remarkable FTlR spectral differences are observed and the differences at the molecular level are extracted between benign
and malignant breast tissue samples. For the malignant tissue, the relative content of nucleic acids is increased whereas
the collagen is decreased. The proteins are phosphorylated and become more flexible and disordered. And these significant
differences have important implications not only for probing the process of the breast lesion at the molecular level, but
also for evaluating the histological types and grades of breast diseases. |
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Keywords: | infrared spectroscopy breast benign and malignant tissues |
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