Inhibition of rat liver glutamine synthetase by phosphonic analogues of glutamic acid期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Inhibition of rat liver glutamine synthetase by phosphonic analogues of glutamic acid

Authors:	B. Lejczak H. Starzemska P. Mastalerz

Affiliation:	(1) Institute of Organic and Physical Chemistry, Technical University, PL-50370 Wrocaw, (Poland)

Abstract:	Summary Analogues of glutamic acid, -methylglutamic acid and glutamine in which the -or -COOH groups are replaced by PO₃H₂ or P(O)(OH₃)OH functions competitively inhibit rat liver glutamine synthetase. The K₁ values are comparable to or lower than K_M for L-glutamate.This study was supported by grant R.1.9.

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