| 高效液相色谱分析阿维菌素(AVM)乳浊液中有效成分B1a和B1b |
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| 引用本文： | 祝莹,张嘉捷,朱岩.高效液相色谱分析阿维菌素(AVM)乳浊液中有效成分B1a和B1b[J].浙江科技学院学报,2003,15(Z1):82-83. |
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| 作者姓名： | 祝莹 张嘉捷 朱岩 |
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| 作者单位： | 浙江大学,化学系,浙江,杭州,310028 |
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| 摘 要： | 阿维菌素(Avermectin,AvM)是一种新型大环内酯类广谱抗寄生虫药物,在我国广为应用.实验采用Dionex 高效液相色谱仪对阿维菌素乳浊液进行分离,紫外检测器检测,结果表明AVMB1a和AVMB1b能与其他干扰峰较好地分离,其中AVMB1a在5～250 mg/L的浓度范围内呈良好的线性关系,回收率为98.8%～100.5%,时间精密度为0.73%,峰面积精密度为0.31%,得到较好的分析结果.
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| 关 键 词： | 阿维菌素 高效液相 抗生素 |
| 文章编号： | 1671-8798(2003)S0-0082-02 |
| 修稿时间： | 2003年9月20日 |
Study on HPLC method for determining avermectin B1a and B1b |
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| ZHU Ying,ZHANG Jia-jie,ZHU Yan.Study on HPLC method for determining avermectin B1a and B1b[J].Journal of Zhejiang University of Science and Technology,2003,15(Z1):82-83. |
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| Authors: | ZHU Ying ZHANG Jia-jie ZHU Yan |
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| Abstract: | Avermectin is a highly potent, broad-spectrum antibiotic, which has excellent effects against various endo-and ecto parasites in animals and plants. In China, avermectin is widely used for domestic animals. In this study, aver-mectins were determined by Dionex high performance liquid chromatography with UV detection. The AVMB1a and AVMB1b were well seperated. For AVMB1a,the range of linear equtation was 5 to 250 mg/L,the average recovery was in the range of 98.8%-100.5% .The relative precision of retention time was 0.73% and its peak area was 0.31 % . |
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| Keywords: | avermectin HPLC antibiotic |
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