Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands |
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Authors: | M Tsuji |
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Institution: | (1) HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, New York, New York 10016, USA |
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Abstract: | Natural killer T (NKT) cells have been shown by a number of studies to play a protective role against cancers, autoimmune
diseases and infectious diseases. Several glycolipids and phospholipids derived from mammalian, bacterial, protozoan and plant
species have recently been identified as natural ligands (antigens) for NKT cells. Some of these glycolipid/phospholipid ligands
have now been crystallized in forms bound to CD1d molecules, and the tertiary structure of these complexes has finally been
revealed. This review is intended to list natural NKT cell ligands identified to date, and discuss how their structures relate
to their propensity to bind CD1d molecules and, as a consequence, stimulate NKT cells.
Received 14 February 2006; received after revision 31 March 2006; accepted 15 May 2006 |
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Keywords: | Glycolipid phospholipid CD1d NKT cell natural ligand |
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