Ethanol influence on insulin secretion from isolated rat islets |
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| Authors: | S P Singh D G Patel A K Snyder G L Pullen |
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| Institution: | (1) Medical Research Service, Veterans Administration Medical Center, 60064 North Chicago, Illinois, USA;(2) Department of Medicine, Chicago Medical School, 60064 North Chicago, Illinois, USA;(3) Present address: Department of Pharmacology, Meharry Medical College, 1005-18th Avenue North, 37208 Nashville, Tennessee, USA |
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| Abstract: | Summary This study was done to delineate the role of  - and  -adrenergic receptors and cyclic AMP in the mechanism of ethanol effects on insulin release from isolated islets. Rats were given an -adrenergic blocker, phentolamine, or a -adrenergic blocker, propranolol. In addition, ethanol 1 g/kg was given intragastrically 1 h prior to sacrifice. Glucose mediated insulin release from isolated islets was enhanced by phentolamine and decreased by propranolol. Ethanol treatment inhibited glucose-induced insulin release from isolated islets of control rats as well as those given phentolamine and/or propranolol. Insulin release from isolated islets in response to dibutyryl-cyclic AMP was attenuated by ethanol. Theophylline enhanced glucose mediated insulin release from control islets but ethanol treatment produced a significant inhibition of insulin response. The data suggest that the site of action of the deleterious effects of ethanol on insulin release from isolated islets in rat does not involve adrenergic system and cyclic AMP.Supported by the U.S. Veterans Administration |
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| Keywords: | Insulin islets ethanol adrenergic receptors cyclic AMP theophylline |
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