The structural relationship of phorbol and cortisol: A possible mechanism for the tumor promoting activity of phorbol |
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| Authors: | S. R. Wilson J. C. Huffman |
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| Affiliation: | (1) Department of Chemistry, Indiana University, 47401 Bloomington, Indiana, USA |
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| Abstract: | ![]()
Summary The crucial functional groups of phorbol-12-myristate-13-acetate (PMA) are superimposable with those of the glucocorticoid cortisol in a unique manner which suggests a mechanism for PMA activity, i.e. the alkylation of a cortisol  receptor . |
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