| 正交试验优化手性镍催化不对称反应条件研究 |
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| 引用本文： | 王恒山,杨燕,童碧海,谢建武,潘英明.正交试验优化手性镍催化不对称反应条件研究[J].广西师范大学学报(自然科学版),2004,22(1):69-73. |
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| 作者姓名： | 王恒山 杨燕 童碧海 谢建武 潘英明 |
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| 作者单位： | 1. 广西师范大学,化学化工学院,天然产物研究与开发重点实验室,广西,桂林,541004
2. 玉林师范学院,化学与生物系,广西,玉林,537000 |
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| 基金项目： | 广西青年基金资助项目(桂青科0229023)，广西教育厅基金资助项目 |
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| 摘 要： | 用正交试验法优化手性镍催化二乙基锌对α，β不饱和酮的不对称麦克尔加成反应条件，优化后的不对称麦克尔加成反应的一般条件为：低温(近反应溶剂冰点)，常压，非质子非极性溶剂(环己烷)．
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| 关 键 词： | 正交试验 镍 不对称麦克尔加成反应 不对称催化 优化 手性分子 |
| 文章编号： | 1001-6600(2004)01-0069-05 |
OPTIMIZING THE CHIRAL NICKEL-CATALYZED ENANTIOSELECTIVE REACTION BY ORTHOGONAL EXPERIMENT METHOD |
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| WANG Heng-shan,YANG Yan,TONG Bi-hai,XIE Jian-wu,PAN Ying-ming College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin ,China.OPTIMIZING THE CHIRAL NICKEL-CATALYZED ENANTIOSELECTIVE REACTION BY ORTHOGONAL EXPERIMENT METHOD[J].Journal of Guangxi Normal University(Natural Science Edition),2004,22(1):69-73. |
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| Authors: | WANG Heng-shan YANG Yan TONG Bi-hai XIE Jian-wu PAN Ying-ming College of Chemistry and Chemical Engineering Guangxi Normal University Guilin China |
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| Institution: | WANG Heng-shan~1,YANG Yan~2,TONG Bi-hai~1,XIE Jian-wu~1,PAN Ying-ming~1 College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin 541004,China, 2.Department of Chemistry and Biology,Yulin Teachers College,Yulin 537000,China) |
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| Abstract: | Based on the new research results of enantioselective catalysis mechanism and the principle of ligand-accelerated catalysis,a general lab method for the reactive condion selection is discussed.System orthogonal experiment method was firstly applied to optimize the title reaction.The method is standardized and programmed and has the characteristics of convenience and reliability.It suits to be used in lab.The common conditions for this reaction after selection include lower temperature (accessing to solvent's (m.p.),)atmosphere,non-protonic and non-polar solvent (hexane). |
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| Keywords: | enantioselective michael addition enantioselective catalysis orthogonal experiment method optimization |
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