健胃舒咀嚼片促进消化功能动物试验研究

目的观察健胃舒咀嚼片对动物胃肠消化功能的影响。方法采用昆明种小鼠进行小肠运动实验,设置阴性对照组、复方地芬诺酯模型对照组和受试物低、中、高剂量组（分别为人群推荐量的10、20、30倍,即0.67g/kg,1.34g/kg,2.01g/kg）。采用Wistar大鼠进行体重、体重增重、进食量和食物利用率试验以及消化酶的测定试验,设置阴性对照组和受试物低、中、高剂量组（分别为人群推荐量的5、10、20倍,即0.34g/kg、0.67g/kg,1.34g/kg）,受试物连续灌胃给予时间为30d。结果小肠运动试验中,低、中、高剂量组小鼠的墨汁推进率均显著高于模型对照组,差异有显著性（P〈0.05、P〈0.05、P〈0.01）。与阴性对照组比较,该受试物各剂量组对大鼠体重、体重增重、进食量及食物利用率无明显影响（P〉0.05）。与阴性对照组比较,各剂量组胃液排出量差异无显著性（P〉0.05）,高剂量组能明显增加胃蛋白酶活性,差异有显著性（P〈0.05）,并且每小时内胃蛋白酶排出量明显增加,差异有显著性（P〈0.01）。结论健胃舒咀嚼片有明显促进消化功能的作用。

Experimental Study of Jian WeiShu Chewable Tablets on Improving Digestion Function of Animal

Objective To observe the effects of JianWeiShu Chewable Tablets on the digestion and absorption function. Methods The Distance of KM mice Knk moving was used to evaluate the effect. The mice were randomly divided into treatment groups, control groups and the Difenoxin model control group. Treatment groups fed with 0.67 g/kg, 1.34 g/kg and 2.01 g/kg dosage（ as 10,20,30 times of population recommended amount respectively）.The body weight, food intakes, food efficiency ratio and the secretion amount of Wistar rats＇ gastric juice and pepsin activity were used to evaLuate the effect. The rats were randomly divided into treatment groups and control groups. Treatment groups fed with 0.34 g/kg,0.67 g/kg and 1.34 g/kg dosage （as 5, 10,20 times of population recommended amount respectively）. JianWeiShu Chewable Tablets were fed through oral for 30 days. Results JianWeiShu Chewable Tablets could increase the rate of ink promoting, which was superior to that in the Difenoxin modeL controL group（ P 〈 0.05）. The body weight, food intakes, food efficiency ratio and the secretion amount of gastric juice of Wistar rats compared with control group showed no obvious differences （p 〉 0.05）. High dosage group also couLd promote the secretion amount of gastric pepsin, pepsin activity, which was superior to that in the control group （p 〈 0.05）. Conclusion JianWeiShu Chewable TabLets has the function of promoting the digestion and absorption function.