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Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes |
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| Authors: | H Haraguchi I Ohmi H Masuda Y Tamura K Mizutani O Tanaka W -H Chou |
| Institution: | (1) Faculty of Engineering, Fukuyama University, Gakuen-cho, 729-02 Fukuyama, (Japan);(2) Biology and Chemistry Laboratory, Maruzen Pharmaceutical Co. Ltd., Sanada Takanishi-cho, 729-01 Fukuyama, (Japan);(3) South China Institute of Botany, The Academy of Science of China, Guangzhou, (China) |
| Abstract: | Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase. |
| Keywords: | Engelhardtia chrysolepis astilbin neoastilbin taxifolin aldose reductase aldehyde reductase NADH oxidase |
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