Action and teleaction of specific ligands on DNA: a quantitative study with Azbel's model and an application to the regulatory mechanism of the lac operon]

Assuming that the action of specific ligands is transferred to DNA via the bases in close contact with the ligand, which are stabilized (or destablized) in this process, the local and more distant action of the ligand on DNA can be evaluated quantitatively with the aid of Azbel's model. An application to the system regulating the E. coli lac operon is presented.