The family of iron responsive RNA structures regulated by changes in cellular iron and oxygen |
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| Authors: | R Leipuviene E C Theil |
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| Institution: | (1) Center for BioIron at CHORI (Children’s Hospital Oakland Research Institute, Children’s Hospital & Research Center at Oakland), 5700 Martin Luther King, Jr. Way, Oakland, California 94609, USA;(2) Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA;(3) Present address: Fermentas UAB, V. Graiciuno g. 8, LT-02241 Vilnius, Lithuania |
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| Abstract: | The life of aerobes is dependent on iron and oxygen for efficient bioenergetics. Due to potential risks associated with iron/oxygen
chemistry, iron acquisition, concentration, storage, utilization, and efflux are tightly regulated in the cell. A central
role in regulating iron/oxygen chemistry in animals is played by mRNA translation or turnover via the iron responsive element
(IRE)/iron regulatory protein (IRP) system. The IRE family is composed of three-dimensional RNA structures located in 3′ or
5′ untranslated regions of mRNA. To date, there are 11 different IRE mRNAs in the family, regulated through translation initiation
or mRNA stability. Iron or oxidant stimuli induce a set of graded responses related to mRNA-specific IRE substructures, indicated
by differential responses to iron in vivo and binding IRPs in vitro. Molecular effects of phosphorylation, iron and oxygen remain to be added to the structural information of the IRE-RNA and
IRP repressor in the regulatory complex.
Received 21 April 2007; received after revision 13 July 2007; accepted 2 August 2007 |
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| Keywords: | Iron oxygen mRNA regulation IRE/IRP system iron regulatory protein iron-responsive element |
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