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| RGD对人纤维肉瘤细胞HT1080增殖、黏附及转移影响的研究 | |
| 引用本文： | 侯瑞珍,王巍,李春蓉,徐力,张学忠.RGD对人纤维肉瘤细胞HT1080增殖、黏附及转移影响的研究[J].东北师大学报(自然科学版),2008,40(1):120-124. |
| 作者姓名： | 侯瑞珍 王巍 李春蓉 徐力 张学忠 |
| 作者单位： | 1. 吉林大学分子酶学工程教育部重点实验室,吉林长春,130023;长春工业大学化工学院,吉林长春,130012 2. 长春工业大学化工学院,吉林长春,130012 3. 吉林大学分子酶学工程教育部重点实验室,吉林长春,130023 |
| 基金项目： | 教育部留学回国人员科研启动基金资助项目，吉林省科技发展计划项目(20070926-03) |
| 摘 要： | 利用合成的RGD(Arg-Gly-Asp)三肽研究了其抑制人纤维肉瘤细胞HT1080的增殖、黏附及转移作用.采用MTT法检测了不同浓度的RGD对HT1080细胞增殖及黏附纤维粘连蛋白(fibronectin)能力的影响;采用细胞划痕法研究了RGD对HT1080细胞在纤维粘连蛋白中迁移能力的影响.结果表明,合成的RGD能抑制HT1080细胞的增殖,并具有抗肿瘤细胞黏附、抗转移的活性. |
| 关 键 词： | 增殖 黏附 肿瘤转移 |
| 文章编号： | 1000-1832(2008)01-0120-05 |
| 修稿时间： | 2007年5月19日 |
Studies on the effects of RGD peptide on the proliferation,adherence and motility of human fibrosarcoma cell HT1080 |
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| HOU Rui-zhen,WANG wei,LI Chun-rong,XU Li,ZHANG Xue-zhong.Studies on the effects of RGD peptide on the proliferation,adherence and motility of human fibrosarcoma cell HT1080[J].Journal of Northeast Normal University (Natural Science Edition),2008,40(1):120-124. | |
| Authors: | HOU Rui-zhen WANG wei LI Chun-rong XU Li ZHANG Xue-zhong |
| Abstract: | The effects of the synthetic tripeptide RGD on the proliferation,adherence andmotility of human fibrosarcoma cell HT1080 have been studied.MTT assay was applied to study the effects of RGD peptide on HT1080 cell proliferation and adhesive capability to Fibronectin.Cellular motility experiment was carried out to assay the inhibitory effect of RGD peptide on HT1080 motility on Fibronectin.The results indicated that RGD peptide had inhibitory effects on the proliferation and adherence of HT1080 cells to fibronectin.It also could restrain motility of HT1080 cells on fibronectin. |
| Keywords: | RGD |
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