Die Sofortwirkung des Thyroxins und ihre klinische Bedeutung

Summary Former investigations have shown, that Thyroxine does not accelerate directly oxidations but the fermentations and that combustions are increased by the breakdown products only. That is why Thyroxine cannot act from the blood, for on the surface of the cells fermentations are stopped by the oxidations because of the Pasteur reaction. Therefore Thyroxine must reach the O₂-poor interior of cells by means of the peripheral nerves. If it is so then in case of the damage of the cells—which is followed as known by the paralysis of the Pasteur reaction—Thyroxine must act directly from the blood without any latency, for then fermentations are no longer stopped at the surface of the cells. The experiments have shown indeed, that if you produce by anemia on white rats a lack of oxygen, Thyroxine increases the oxidations up to 50% already in about 30 minutes which in the case of normal animals cannot be expected before 24 hours. It is probable that in the case of the general damage of cells (serious anemia, uncompensated heart defects, tumors) the noticeable loss in weight and cachexia are conditioned by that Thyroxine which circulates in the blood-stream and they may be cured by remedies such as Thiouracil or Thermothyrine.