Causes of oxidative stress in Alzheimer disease |
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| Authors: | X Zhu B Su X Wang M A Smith G Perry |
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| Institution: | (1) Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA;(2) College of Sciences, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, USA |
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| Abstract: | Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the
onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular
damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated
damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other
factors. In this review, we provide an overview of these potential causes of oxidative stress in AD. |
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| Keywords: | Alzheimer disease amyloid-β antioxidant iron metals mitochondria oxidative stress pathogenesis phosphorylation reactive oxygen species tau |
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