Dependence receptors: between life and death |
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Authors: | Mehlen P Thibert C |
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Institution: | (1) Apoptosis/Differentiation Laboratory, Equipe labelisée La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France;(2) The Buck Institute for Age Research, 94945 Novato, California, USA |
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Abstract: | The recently described family of dependence receptors is a new family of functionally related receptors.
These proteins have little sequence similarity but display the common feature of inducing two completely opposite
intracellular signals depending on ligand availability: in the presence of ligand, these receptors transduce a
positive signal leading to survival, differentiation or migration, while in the absence of ligand, the receptors
initiate or amplify a negative signal for apoptosis. Thus, cells that express these proteins manifest a state of
dependence on their respective ligands. The mechanisms that trigger cell death induction in the absence of ligand
are in large part unknown, but typically require cleavage by specific caspases. In this review we will present the
proposed mechanisms for cell death induction by these receptors and their potential function in nervous system
development and regulation of tumorigenesis.Received 19 December 2003; received after revision 19 February 2004; accepted 26 February 2004 |
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Keywords: | Dependence receptor apoptosis development tumor suppressor caspase |
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