Effect of platelet activating factor on guinea-pig papillary muscle |
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| Authors: | G. Camussi Dr G. Alloatti G. Montrucchio M. Meda G. Emanuelli |
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| Affiliation: | (1) Laboratorio di Immunopatologia, Ospedale di S. Giovanni Battista e della Città di Torino, Torino, (Italy);(2) Present address: Istituto di Fisiologia Generale, Università degli Studi di Torino, Torino, (Italy) |
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| Abstract: | ![]()
Summary Platelet activating factor (PAF) induces a biphasic effect on guinea-pig papillary muscle: 1. a transient positive inotropic effect preceded by an increase in action potential duration (APD); 2. a marked negative effect on inotropism and on APD. Since Ca++ slow action potentials were initially enhanced by PAF and then markedly depressed, it is suggested that PAF specifically interferes with the Ca++ slow channel. |
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