| 工业生物过程优化与放大研究中的科学问题——生物过程环境组学与多尺度方法原理研究 |
| |
| 引用本文： | 张嗣良.工业生物过程优化与放大研究中的科学问题——生物过程环境组学与多尺度方法原理研究[J].中国基础科学,2009,11(5):27-31,13. |
| |
| 作者姓名： | 张嗣良 |
| |
| 作者单位： | 华东理工大学生物反应器工程国家重点实验室,上海,200237 |
| |
| 基金项目： | 国家973计划，863计划，支撑计划 |
| |
| 摘 要： | 本文首先通过实例阐述了基于生物反应器生物过程多尺度分析的过程优化技术和基于细胞生理特性与生物反应器流场特性研究相结合的生物过程放大技术原理和应用方法，并根据生物过程环境对生物细胞生理特性的影响，提出把环境组学作为系统生物学研究的一部分，用系统生物学的方法对生物过程开展全域性（global）研究，即基于生物过程信息处理的生物过程系统工程研究，以期进一步推动我国生物反应器生物过程优化与放大研究的深入开展。
|
| 关 键 词： | 生物反应器 生物过程优化 系统生物学 生物过程学放大 环境组学 生物过程系统工程 |
Systems Bioprocess Engineering: New Insights into the Optimization and Scale-up of Industrial Fermentation Processes |
| |
| Zhang Siliang.Systems Bioprocess Engineering: New Insights into the Optimization and Scale-up of Industrial Fermentation Processes[J].China Basic Science,2009,11(5):27-31,13. |
| |
| Authors: | Zhang Siliang |
| |
| Institution: | Zhang Siliang (State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237) |
| |
| Abstract: | The current strategies for industrial bioprocess optimization and scale-up were presented firstly by several practical examples.Then the interactions between environments in a bioreactor and the metabolism of cells were discussed in detail and it was concluded that the envirome should be a crucial element to be considered in the study of bioprocess in the context of systems biology.Finally systems bioprocess engineering, a new strategy for the optimization and scale-up of industrial fermentation processes, was put forward based on the integrated analysis and utilization of all information collected from outside and inside cells in a bioreactor. |
| |
| Keywords: | bioreactor bioprocess optimization systems biology bioprocess scale-up envirome systems bioprocess engineering |
| 本文献已被 维普 万方数据 等数据库收录！ |
