<Emphasis Type="Italic">Legionella pneumophila</Emphasis> — a human pathogen that co-evolved with fresh water protozoa |
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Authors: | C Albert-Weissenberger C Cazalet C Buchrieser |
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Institution: | Unité de Génomique des Microorganismes Pathogènes and CNRS URA 2171, Institut Pasteur, 25 Rue du Dr Roux, 75724, Paris Cedex 15, France. cbuch@pasteur.fr |
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Abstract: | The bacterial pathogen Legionella pneumophila is found ubiquitously in fresh water environments where it replicates within protozoan hosts. When inhaled by humans it can
replicate within alveolar macrophages and cause a severe pneumonia, Legionnaires disease. Yet much needs to be learned regarding
the mechanisms that allow Legionella to modulate host functions to its advantage and the regulatory network governing its intracellular life cycle. The establishment
and publication of the complete genome sequences of three clinical L. pneumophila isolates paved the way for major breakthroughs in understanding the biology of L. pneumophila. Based on sequence analysis many new putative virulence factors have been identified foremost among them eukaryotic-like
proteins that may be implicated in many different steps of the Legionella life cycle. This review summarizes what is currently known about regulation of the Legionella life cycle and gives insight in the Legionella-specific features as deduced from genome analysis.
Received 1 September 2006; received after revision 10 October 2006; accepted 22 November 2006 |
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Keywords: | Legionella pneumophila Legionnaires disease pathogenesis eukaryotic-like proteins |
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