Effects of dosage and cadmium pretreatment on the binding of cadmium in rat bile |
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Authors: | M Cikrt J Havrdová |
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Institution: | (1) Institute of Hygiene and Epidemiology, Centre of Industrial Hygiene and Occupational Health, robárova 48, 10042 Prague 10, (Czechoslovakia) |
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Abstract: | Summary The effects of dosage and of cadmium pretreatment on the binding of cadmium in rat bile were studied. With increasing dose a higher cumulative biliary excretion of Cd was observed and a higher percentage of the Cd was excreted in a low-molecular-weight form. On the other hand, after cadmium pretreatment, a decrease in the cumulative biliary excretion of cadmium was observed but a greater percentage of that excreted into the bile was bound to high molecular weight compounds. |
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