Modified DTPA,EDTA ligands and their paramagnetic metal complexes as contrast agents for MRI |
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| Authors: | Zhuo Renxi Fu Gongcheng Ouyang Ming Zhao Xia Lu Zhengrong |
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| Institution: | (1) Department of Chemistry, Wuhan University, 430072 Wuhan, China |
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| Abstract: | Six new aminocarboxylic ligands were synthesized by reactions of EDTA (ethylenediaminetetraacetic acid) dianhydride or DTPA
(diethylenetriaminepenta—acetic acid) dianhydride and ethyl ester of serine, threonine and tyrosine. Their paramagnetic metal
complexes were also synthesized. All ligands and paramagnetic metal complexes were characterized by IR spectra,1H NMR and elemental analyses. Relaxivity study showed that the metal complexes had higher relaxation effectiveness as compared
to corresponding unmodified metal complexes. Imaging study of gadolinium complex of tyrosine ethyl ester modified DTPA in
mice demonstrated that this metal complex could apparently increase the signal intensity of MR images.
Supported by the National Natural Science Foundation of China
Zhuo Renxi, born in Feb. 1931, professor |
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| Keywords: | magnetic resonance imaging (MRI) contrast agent relaxivity derivative of amino acid |
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