基于移动数据库的异构数据一致性技术研究

从移动数据库体系结构的演变、数据一致性技术的分类和异构数据同步协议(SyncML)的架构等3个方面介绍了基于移动数据库的异构数据的一致性技术，并结合三者优势提出了DM／SMDS模型，为移动环境下快速、高效地实现数据收敛提供了一种可行的解决方案。     

RNA interference-mediated inhibition of Hepatitis B Virus replication

Persistent and recurrent infection of hepatitis B virus (HBV) represents one of the most common and severe viral infections of humans, and has caused a formidable health problem in the affected countries. Currently used antiviral drugs have a very limited success on controlling HBV replication and infection. RNA interference (RNAi), a process by which double-stranded RNA (dsRNA) directs sequence-specific degradation of target mRNA in mammalian and plant cells, has recently been used to knockdown gene expression in various species. In this study, we sought to determine whether RNAi-mediated silencing of HBV viral gene expression could lead to the effective inhibition of HBV replication. We first developed RNAi vectors that expressed small interfering RNA (siRNA) and targeted the HBV core or surface gene sequence. Our results demonstrated that these specific siRNAs efficiently reduced the levels of corresponding viral RNAs and proteins, and thus suppressed viral replication. Treatment with siRNA gave the greatest reduction in the levels of HBsAg (92%) and in HBeAg (85%) respectively in the cultured cell medium. Our findings further demonstrated that the RNAi-mediated antiviral effect was sequence-specific and dose-dependent. Therefore, our findings strongly suggest that RNAi-mediated silencing of HBV viral genes could effectively inhibit the replication of HBV, hence RNAi-based strategy should be further explored as a more efficacious antiviral therapy of HBV infection.     

AMS实验中的副本管理研究

提出了一种新的副本管理策略同时结合了预测和淘汰代价因素.通过预测副本在未来时间窗内的流行程度,热点副本被保留下来可以提高平均作业响应时间.代价因素主要关注的是副本的替换代价诸如网络延时和带宽,以及副本尺寸.经过使用OptorSim仿真器对AMS国际合作实验中数据的仿真模拟,比较副本管理策略和传统的替换算法的性能,结果表明管理策略在平均工作时间和带宽消耗方面取得了很好的平衡.     

无线传感网络中空间失效模式下的数据存储恢复算法

针对空间失效模式下的数据存储和恢复问题,设计了一种基于数据复制的存储和恢复算法.该算法为每个数据节点分配一个冗余节点,在数据节点失效时可以利用冗余节点中的数据来成功恢复数据,并且使整个过程消耗的代价最小.理论分析和仿真实验表明,同Greedy算法相比,在保证成功恢复的同时,该方法显著降低了网络的整体能耗,从而有效延长了网络的生存周期.     

点突变积累与分子进化

认为木村资生等人用分子进化的中性说向综合达尔文进化说提出了挑战，但在许多方面他们又未能摆脱综合进化说的概念框架和理论范式。进而从对分子进化有更深层意义的复制群体中的基因点突变特征入手，初步提出了一个分子进化的点突变积累模型，并以此解释了分子进化钟的成因，指出了现存物种高低分布与物种历史进化之间在分子水平上的渊源关系。     

A New Primary Lazy Update Propagation Protocol for Replicated Databases

This paper proposes a new primary lazy update protocol, PTCS （Primary Transaction Commit Schedule）. In the PTCS protocol, a serializable primary transaction schedule is generated firstly and then the secondary transactions are committed according to the serializable primary transaction schedule. PTCS protocol can guarantee serializability if the data copy graph contains no directed circles. It can also be ex tended to eliminate all requirements on the data copy graph. Compared to earlier works, PTCS protocol not only imposes a much weaker requirement on the data placement, but also avoids the deadlock caused by transaction waits and extra message overhead. The performance experiments show that the degradation of the performance caused by the replica man- agement of the PTCS protocol is tolerable.     

移动学习中的复制服务器的动态选择方案研究

移动学习是一种移动计算环境中的WEB服务，可采用复制WEB服务器的策略提高响应性，移动数据库技术的三级复制机制能比较完美地适应移动学习过程的特性，对于其第一级复制-服务器级复制存在这样的特点，分布于不同的地理位置的多个复制服务器，能为用户提供的服务质量是不同的，而且是动态变化的，所以如何选择复制服务器为移动用户提供服务是一个关键问题，提出了以客户为中心的负荷分布机制保证移动学习的可用性和响应性，并选择在WAP网关实现该机制。     

SU(N)超弦前子最大模型的探讨

本文在超对称和渐近自由要求下,构造了具有代复制机制的SU(N)最大超弦前子模型,给出四代复合轻子夸克。