混合加速寿命试验模型下威布尔分布参数的统计分析

在混合加速寿命试验模型（序进应力加速寿命试验和恒定应力加速寿命试验相结合）下，讨论了寿命分布为威布尔分布时的参数估计问题，给出了形状参数的逆矩估计以及加速系数的置信区间．并且随机模拟一组样本，验证了这个方法的有效性．     

Optimum design of equivalent accelerated life testing plans based on proportional hazards-proportional odds model

The optimum design of equivalent accelerated life testing plan based on proportional hazards-proportional odds model using D-optimality is presented.The defined equivalent test plan is the test plan that has the same value of the determinant of Fisher information matrix.The equivalent test plan of step stress accelerated life testing(SSALT) to a baseline optimum constant stress accelerated life testing(CSALT) plan is obtained by adjusting the censoring time of SSALT and solving the optimization problem for each case to achieve the same value of the determinant of Fisher information matrix as in the baseline optimum CSALT plan.Numerical examples are given finally which demonstrate the equivalent SSALT plan to the baseline optimum CSALT plan reduces almost half of the test time while achieving approximately the same estimation errors of model parameters.     

加速寿命试验下随机截尾指数寿命数据的Beyes统计分析

本文针对恒定应力加速寿命试验下，进行随机截尾指数寿命数据的Ｂａｙｅｓ分析，在未知加速寿命方程情况下，给出了常应力下分布参数的后验分布及其Ｂａｙｅｓ估计．最后给出了两个计算实例．     

ALT法设计曲柄摇杆机构

本文在ALT按死点位置,运用作图法求解四连杆机构的基础上,提出了一套解析方法。可在许用范围内优选机构尺度,为设计曲柄摇杆机构提供了一种简捷方法。     

乌索酸与齐墩果酸对小鼠实验性肝损伤保护作用的比较

为了研究乌索酸的保肝作用及其特色，分别建立四氯化碳(CCl4)、D-氨基半乳糖胺(D—GaIN)、卡介苗加脂多糖(BCG—LPS)及异硫氰酸-1-萘酯(ANT)诱导小鼠肝脏损伤模型，以测定血清谷丙氨酸转换酶(ALT)、谷草氨基酸转换酶(AST)、总胆红素(113)和肝组织丙二醛(MDA)含量为指标，观察乌索酸对肝脏损伤的保护作用，并与抗肝炎药物齐墩果酸进行比较，结果表明：30mg／kg乌索酸均能显著降低CCl4、D—GalN、BCG—LPS、ANIT致肝损伤小鼠血清ALT和肝MDA值，而30mg,／kg齐墩果酸对CCl4、BCG—LPS肝损伤小鼠降ALT效果不及乌索酸；30mg／kg乌索酸能非常显著地降低ANIT致肝损伤小鼠血清TBLL含量，而30mg／kg齐墩果酸与联苯双酯降血清TB作用不明显，提示：乌索酸具有明显的降酶、退黄保肝作用。     

Biological correlates of psychological states among young children: a cross-sectional examination of roles of aspartate transaminase/alanine aminotransferase,insulin, and cytokines

Compared to data on adolescents and adults, limited research has been conducted on biological corre- lates among young children with possible psychological difficulties, especially in Asian countries. By focusing on various peripheral biochemical indicators, we investigated potential biological correlates of psychological states in a community sample of Taiwanese school children aged 6-10 years. In total, 307 students （159 obese children and 148 normal-weight children） were selected from first- and fourth-grade school children in eight elementary schools in the Taipei metropolitan area in 2009. These children underwent a comprehensive health examination, including a physical examination, blood sample analysis, and questionnaire administration in a hospital. Differences in anthropometric and serum biochemical readings were compared between children with average and worse levels on each of the five psychological domains. We found that interleukin （IL）-1β [β = 1.29, 95 % confidence interval （CI） 0.50-2.09], IL-10 （β = 1.61, 95 % CI 〈0.01-3.24）, fasting blood glucose （β = 0.08, 95 % CI 0.01-0.15）, homocysteine （β = 0.63, 95 % CI 0.09-1.18）, and aspar- tate transaminase （AST） （β = 0.15, 95 % CI 〈0.01-0.31） were significantly positively associated with anxiety. In addition, IL-113, insulin, AST, and alanine aminotransam- inase （ALT） were significantly positively associated with depression. Anger and disruptive behaviors were also related to specific biological correlates. Specific biological correlates, including AST/ALT, cardiovascular disease- related variables, and specific cytokines, were linked to particular psychological states among young children in this Asian population. These might provide a route for better understanding the biological aspects of children＇s mental health and might contribute to research on diag- nostic or predictive biomarkers for psychiatric diseases in young children.     

指数分布下定数截尾步加试验参数的二次顺序约束Bayes估计

给出了2种方法,把指数分布下k个应力水平定数截尾步加试验数据转化为对应的恒加试验数据,然后利用恒加试验的结果,给出了在应力水平Si下产品平均寿命的经验分布估计和二次Bayes估计.     

速率法、丙酮酸氧化酶法与微板赖氏法检测ALT的对比试验

目的：为血站筛查ALT选择较准确可靠的试验方法提供试验依据．方法：由内蒙古通辽市中心血站提供的63份ALT含量不同的血浆标本进行速率法（简称S法）、丙酮酸氧化酶法（简称B法）与微板赖氏法（简称L法）比较．结果：L法、S法、B法的中值定值血清（接近血站的判断标准）,板内变异系数依次为7．03％、3．98％、2．47％;L法、S法、B法的中值定值血清板间变异系数依次为7．86％、5．75％、5．50％．结论：微板丙酮酸氧化酶法可以作为血站筛查ALT的方法．     

硅雪崩光电探测器加速工作寿命试验应用研究

为了通过加速寿命试验评估硅雪崩光电探测器的工作寿命,通过FMEA分析和摸底试验,确定了硅雪崩光电探测器的主要失效模式、敏感应力和极限应力,设计并实施了加速工作寿命试验,得到了与理论分析和摸底试验相同的结果:温度应力是影响硅雪崩光电探测器工作寿命的主要应力,最高工作温度应力极限是130℃,对温度应力敏感的参数是暗电流和前放静态输出电压,验证了加速工作寿命试验方案的合理性和可行性。     

Inference for constant-stress accelerated life test with Type-I progressively hybrid censored data from Burr-Xll distribution

This paper proposes a simple constant-stress accel- erated life test （ALT） model from Burr type XII distribution when the data are Type-I progressively hybrid censored. The maximum likelihood estimation （MLE） of the parameters is obtained through the numerical method for solving the likelihood equations. Approxi- mate confidence interval （CI）, based on normal approximation to the asymptotic distribution of MLE and percentile bootstrap Cl is derived. Finally, a numerical example is introduced and then a Monte Carlo simulation study is carried out to illustrate the pro- posed method.