Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

（BN）n及SiB（n-1）Nn（n=2-11）稳定结构的研究

利用遗传算法及Gastreich提出的经验势函数,研究了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇的可能稳定结构,对能量较低的异构体在HF/STO-3G水平进行优化,得到了（BN）n（n=2-11）和SiBn-1Nn（n=2-11）团簇稳定结构单环及线状结构,并进一步分析了单环的结构特征及相对稳定性。     

生物荧光激发滤光片及栅滤光片的研制

本文论述生物荧光激发滤片及栅滤光片的膜系设计，压缩滤光片通带的新方法以及制备滤光片所采取的工艺措施。     

One modified method of characteristics used to analyze the multiconductor transmission lines

1.INTRODUCTIONThe analysis of electromagnetic compatibility becomesmorei mportant in the analysis of the multiconductortransmissionlines(MTLs).It provides the effectivemethod for designing the MTLs.Several methodsbased on frequency domain and ti me domain tech-niques have beenrecently proposed[1,2].Thefrequen-cy method should performthe inverse Fourier trans-formation,so it is not more accurate than ti memethod to some degree.The method of characteris-ticsis based ontheti me domain met…     

TCP拥塞控制分析模型

介绍了研究传输控制协议 (TCP)拥塞控制问题的各种分析模型 ,指出了研究TCP拥塞控制的主要目标 .对当前国内外的研究动态给予了讨论 ,并对当前现有模型根据其流量范围和使用的分析工具进行了分类概括 .最后概要地阐述了在端到端和在网络中进行拥塞控制的相互关系     

基于集总电感传输线建模的控制系统数字仿真

应用集总电感元件的传输线建模方法(TLM)构造了一种基于数值求解微分方程的数字仿真算法。通过把状态变量对应于电感中的电流，利用电感元件的传输线模型得到状态方程的仿真模型来实现控制系统的数字仿真计算。由于TLM方法是以传输线的等效无源线性网络作为建模基础，从而使算法具有无条件的数值稳定性。     

Windows NT下视频传输卡的多卡驱动程序开发方法

由于WindowsNT操作系统不允许应用程序直接操纵硬件,从而给开发与硬件结合的软件项目带来了一定的困难,因而如何进行硬件驱动程序的编写就成了Windows环境下一个重要的程序开发领域。给出了WindowsNT系统下基于PCI总线的硬件设备驱动程序开发的一般方法,以及如何运用SoftICE来进行驱动程序跟踪调试的一般方法,最后给出了一种同时支持多块视频传输卡的多卡驱动程序的开发方法。     

变速齿轮传动系统最佳轴向结构布局智能设计的推理机制

本文通过对变速齿轮传动系统轴向结构布局设计规律的研究,提出了一种适合于该类问题的知识表达方式,将改进后的带有启发函数的最佳优先搜索方法引入到该问题的求解中,使得含有多重搜索空间以及带有一定约束的设计问题统一在同一搜索策略下。根据本文提出的方法,用PROLOG语言建造的推理机,通过对实际问题的考证,证明该方法在解决传动结构自动设计上是行之有效的,并且在推理机制上成功地体现了设计过程中反复设计与优化设计的功能特征.     

基于Modbus、Modbus Plus的交流传动网络的研究

简要介绍了Schneider公司的Modbus和Modbus Plus总线,并提出了基于Modbus和Modbus Plus的交流传动控制网络.重点讨论了此控制网络的系统配置和梯形图设计,这种控制网络控制方便,传输精度高.     

具有许用传动角和最显著急回特性的平面曲柄滑块机构设计

以“辅助角方法”为理论基础 ,提出并解决了按一并具有许用传动角 [γ]和最显著急回特性Kmax之条件设计平面曲柄滑块机构的理论课题 .