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中华鳖嗜水气单胞菌病的研究 总被引:2,自引:0,他引:2
陈建酬 《佛山科学技术学院学报(自然科学版)》2000,18(4):69-72
概述了由嗜水气单胞菌所引起中华鳖的各种疾病、病理症状、致病原因和机理,以及疾病防治的研究。 相似文献
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CHENJuan LIHong-lian FENGYou-mei WANGjian-zhi 《武汉大学学报:自然科学英文版》2005,10(2):472-476
Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks of Alzheimer‘s disease (AD) and abnormally hyperphosphorylated tau is the major protein of NFTs. It was reported that cyclin-dependent kinase5 (Cdk-5) could phosphorylate tau at most AD-related epitopes in vivo. In this study, we investigated the effect of cdk-5 overexpression on tau hyperphosphorylation in neuroblastoma N2a cells. We demonstrated that overexpression of cdk-5 whieh rcsul-ted in a 3.5-fold Cdk-5 activation in the transfected cells induced a dramatic increase in phosphorylation of tau at several phosphorylation sites. Overexpression of cdk-5 led to a reduced staining with antibody Tau-1 and an enhanced staining with antibody PHF-1, suggesting hyperphosphorylation of tau at Ser199/202 and Ser396/404 sites. It implies that in vitro overexpression of cdk-5 leads to Cdk-5 overactivation and tau hyperphosphorylation may be the underline mechanism. 相似文献
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