排序方式: 共有131条查询结果,搜索用时 28 毫秒
1.
Finding finer functions for partially characterized proteins by protein-protein interaction networks
LI YanHui GUO Zheng MA WenCai YANG Da WANG Dong ZHANG Min ZHU ding ZHONG GuoCai LI YongJin YAO Chen WANG Jing 《科学通报(英文版)》2007,52(24):3363-3370
Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins. 相似文献
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在概述语义WEB的基础上,设计一个面向学习者用户网站的语义WEB体系结构,提出了多代理结构的学习支持系统中的学习者模型本体和学习者模型代理.目的是为了说明建立学习者本体及其代理对于学习者的有效学习所带来的益处. 相似文献
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针对传统英语语料库的缺陷,提出了对英语语料建立本体的新型语料库,并对基于Ontology在Web上挖掘英语语料做出了详细的阐述.对在Web上进行语料挖掘的几个关键技术作了不同程度的说明,并对此语料挖掘系统做出了评价. 相似文献
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基于Web Services的虚拟文物博物馆架构 总被引:8,自引:1,他引:8
分布于各处的数字博物馆异构特性使它们之间难以互通互联,这使数字博物馆的优越性难以充分发挥。Web Services将集成技术延伸到了Web上,是目前集成异构平台的理想实现技术。基于本体(Ontology)的数据表示模型为更好的进行语义检索提供了基础。探讨和设计将以上技术用于构建网上虚拟文物博物馆,给出采用这种架构设计的系统的性能测试结果与比较评价。 相似文献
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本体映射作为实现多本体间相互操作的重要手段,已广泛应用于诸多领域.应用原始RankRLS算法,将多本体图映射到实数轴,由此将本体图中每个顶点都映射成实数.通过比较两概念对应实数间的差值得到本体映射.实验表明,该算法有较高的效率. 相似文献
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在分析本体构建方法的基础上,利用软件工程思想,提出了一种民族教育资源本体构建方法,并以傣族教育资源本体构建及实现为例,详细阐述了傣族教育资源概念的获取、层次结构的划分、概念的属性和关系的确定以及实例的创建,最后基于Protege实现了该本体。 相似文献
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XU Youwei TANG Shengqun YANG Yan XU Yang LI Ling 《武汉大学学报:自然科学英文版》2007,12(2):243-248
We proposed an Intemet resource aggregation platform based on semantic web. The platform includes an Web Ontology Language(OWL) ontology design toolkit(VO-Editor) and a selective inference algorithm engine so that it can visually editing ontology and using novel selective reasoning for information aggregation. We introduce the VO-Editor and the principle of selective inference algorithm. At last a case of budget travel system is used to interpret the approach of Internet resources aggregation by this platform. 相似文献
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教育本质的论争之所以陷入“疑无路”的境地,根本在于论争只是囿于探究知识论的“教育是什么”而遗忘了追寻存在论的“怎样教育”这一教育之“根”与“本”,以致教育之本质与语言遭际异化。缘此,本文拟在反思以往教育本质论争的基础上,试图走向“怎样教育”,以期扬弃异化,返朴归真。 相似文献
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目的针对传统W eb信息检索模型的不足,提出一种基于语义的W eb信息检索模型。方法模糊相关技术、Ontology及W eb挖掘技术。结果建立了一种五元组的语义信息检索模型,并给出了该模型的关键实现算法。结论利用此模型实现的信息检索系统进行信息检索时具有更高的准确率和查全率。 相似文献