Influence of Mg_5Ga_2 compound on microstructures and electrochemical properties of Mg-5%Hg-22%Ga alloy

The Mg-5%Hg-22%Ga(mole fraction) alloy was melted.Aging at 573-673 K for different times was carried out to ensure the fine dispersion of the Mg_5Ga_2 compound.Scanning electron microscopy(SEM),X-ray diffractometry(XRD) and energy spectrum analysis(ESA) were employed to characterize the microstructures and phases of the Mg-5%Hg-22%Ga alloy.The electrochemical and corrosion behaviors of the above alloy were studied by potentiodynamic,galvanostatic and electrochemical impedance spectroscopy(EIS) measuremen...     

GFC-空间中的参数型KKM定理及其应用

首先证明了GFC-空间的一个特征性质,然后通过引进线性序空间,在非紧的GFC-空间中证明了一个参数型KKM定理.应用参数型KKM定理得到了一些新的非紧的极大极小不等式.     

Primary Structural and Quantitative Analysis of Infeasible Solution to Job shop Scheduling Problem

1　IntroductionTheJobShopSchedulingProblemisawell-knownNP-hardproblem,whichattractslotsofmathematiciansallovertheworldspendingmuchtimeandenergyinthisfield.Uptonowtherearemanyefficientheuristicalgorithms,whichhadalreadybeendeveloped,buttheinfeasiblesolutioncertainlypossessesthemajorityofsearchspacewhichhasinfluencedtheefficiencyofthesealgorithms.Atthemoment,noonehasbeenfoundtobededicatingtothequantitativeanalysisoftheinfeasiblesolutionproblem.InthispaperthestructureofinfeasiblesolutiontoJSS…     

Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure.

Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,000 live births among individuals of European descent. The secondary palate arises as bilateral outgrowths from the maxillary processes, and its formation depends on the coordinated development of craniofacial structures including the Meckel's cartilage and the mandible. Cleft lip and palate syndromes in humans are associated with polymorphisms in the gene (TGFA) encoding transforming growth factor-alpha (TGF-alpha), an epidermal growth factor receptor (EGFR) ligand made by most epithelia. Here we have characterized craniofacial development in Egfr-deficient (Egfr-/-) mice. Newborn Egfr-/- mice have facial mediolateral defects including narrow, elongated snouts, underdeveloped lower jaw and a high incidence of cleft palate. Palatal shelf explants from Egfr-/- mice fused, but frequently had residual epithelium in the midline. In addition, morphogenesis of Meckel's cartilage was deficient in cultured mandibular processes from Egfr-/- embryos. The secretion of matrix metalloproteinases (MMPs) was diminished in Egfr-/- explants, consistent with the ability of EGF to increase MMP secretion and with the decreased MMP expression caused by inhibition of Egfr signalling in wild-type explants. Accordingly, inactivation of MMPs in wild-type explants phenocopied the defective morphology of Meckel's cartilage seen in Egfr-/- explants. Our results indicate that EGFR signalling is necessary for normal craniofacial development and that its role is mediated in part by its downstream targets, the MMPs, and may explain the genetic correlation of human cleft palate with polymorphisms in TGFA.     

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Effective targeted cancer therapeutic development depends upon distinguishing disease-associated 'driver' mutations, which have causative roles in malignancy pathogenesis, from 'passenger' mutations, which are dispensable for cancer initiation and maintenance. Translational studies of clinically active targeted therapeutics can definitively discriminate driver from passenger lesions and provide valuable insights into human cancer biology. Activating internal tandem duplication (ITD) mutations in FLT3 (FLT3-ITD) are detected in approximately 20% of acute myeloid leukaemia (AML) patients and are associated with a poor prognosis. Abundant scientific and clinical evidence, including the lack of convincing clinical activity of early FLT3 inhibitors, suggests that FLT3-ITD probably represents a passenger lesion. Here we report point mutations at three residues within the kinase domain of FLT3-ITD that confer substantial in vitro resistance to AC220 (quizartinib), an active investigational inhibitor of FLT3, KIT, PDGFRA, PDGFRB and RET; evolution of AC220-resistant substitutions at two of these amino acid positions was observed in eight of eight FLT3-ITD-positive AML patients with acquired resistance to AC220. Our findings demonstrate that FLT3-ITD can represent a driver lesion and valid therapeutic target in human AML. AC220-resistant FLT3 kinase domain mutants represent high-value targets for future FLT3 inhibitor development efforts.     

以Aliquat336为流动载体的乳状液膜迁移和分离Mo（Ⅵ）的研究

用Aliquat336—Span80—煤油乳状液膜体系 ,研究Mo(Ⅵ )的迁移行为。在适宜条件下 ,5min内Mo(Ⅵ )的迁移率可达 96%以上 ,并能与Fe2 、Cu2 、Co2 、Ni2 、Zn2 、Cd2 、Mn2 等常见离子分离     

基于收益率与风险比率的期货套期保值策略研究

引入目标收益率作为衡量套期保值行为盈亏的界线,建立基于改进的收益率与风险比率相对数最大化的期货套期保值优化决策模型。使得单位风险下组合期望收益率大于目标收益率的收益程度最大,从理论上推导出空头和多头套期保值的最优套期比率,并与传统套期比作比较,求出了空头和多头在传统最优套期比基础上的调整量。给出了当目标收益率满足一定条件时,空头和多头套期保值的最优套期比公式。     

图像处理技术在乘用车侧面碰撞试验中的应用

多媒体计算机序列图像运动分析系统与摄影测量学理论相结合,成为较完善的非接触动态测量系统.在乘用车侧面碰撞试验中采用图像采集和数字图像处理技术,结合直接线性变换(direct liner transformation,DLT)算法,分析碰撞试验中标示点的变形量,提高乘用车侧面碰撞强度,为汽车被动安全性研究提供依据.     

Urease. VIII. Its interaction with sodium dodecyl sulfate

Riassunto Il dodecilsolfato di sodio causa la dissociazione dell'urease (massa molecolare 480,000) in una maniera che dipende fortemente sulla concentrazione relativa dei reagenti. Il prodotto ottenuto con un sufficiente eccesso di detergente ha una massa molecolare di 50,000–60,000.

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This work was supported by Grant No. 11,573 and Career Award No. 5K3 GM 13,489 (to G.G.) from the National Institutes of Health, Department of Health, Education and Welfare.