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1.
以中尼公路卡如滑坡为例,详细地分析了该滑坡的变形特征及成因机制。研究表明,地形及滑坡体的物质组成特征是滑坡的地质基础,大量降雨是滑坡的促进因素,公路修建对滑坡前部的开挖是滑坡的直接诱发因素。针对卡如滑坡的特点,提出了相应的治理工程措施。 相似文献
2.
Didier Vilette Josquin Courte Jean Michel Peyrin Laurent Coudert Laurent Schaeffer Olivier Andréoletti Pascal Leblanc 《Cellular and molecular life sciences : CMLS》2018,75(14):2557-2574
Prions are infectious agents that cause fatal neurodegenerative diseases. Current evidence indicates that they are essentially composed of an abnormally folded protein (PrPSc). These abnormal aggregated PrPSc species multiply in infected cells by recruiting and converting the host PrPC protein into new PrPSc. How prions move from cell to cell and progressively spread across the infected tissue is of crucial importance and may provide experimental opportunity to delay the progression of the disease. In infected cells, different mechanisms have been identified, including release of infectious extracellular vesicles and intercellular transfer of PrPSc-containing organelles through tunneling nanotubes. These findings should allow manipulation of the intracellular trafficking events targeting PrPSc in these particular subcellular compartments to experimentally address the relative contribution of these mechanisms to in vivo prion pathogenesis. In addition, such information may prompt further experimental strategies to decipher the causal roles of protein misfolding and aggregation in other human neurodegenerative diseases. 相似文献
3.
A general complex delayed dynamical network model with asymmetric coupling matrix is considered in this paper. For reducing
the conservativeness of synchronization criteria, several novel synchronization stability conditions are presented by using
delay decomposition methods. Numerical examples which are widely used to study delay-dependent synchronization stability are
given to illustrate the effectiveness of the proposed methods. 相似文献
4.
This paper presents a methodology which determines the allocation of power demand among the committed generating units while minimizes number of objectives as well as meets physical and technological system constraints. The procedure considers two decoupled problems based upon the dependency of their goals on either active power or reactive power generation. Both the problems have been solved sequentially to achieve optimal allocation of active and reactive power generation while minimizes operating cost, gaseous pollutants emission objectives and active power transmission loss with consideration of system operating constraints along with generators prohibited operating zones and transmission line flow limits. The active and reactive power line flows are obtained with the help of generalized generation shift distribution factors (GGDF) and generalized Z-bus distribution factors (GZBDF), respectively. First problem is solved in multi-objective framework in which the best weights assigned to objectives are determined while employing weighting method and in second problem, active power loss of the system is minimized subject to system constraints. The validity of the proposed method is demonstrated on 30-bus IEEE power system. 相似文献
5.
This paper studies the first passage time problem for a reflected two-sided jump-diffusion risk model with the jumps having a hyper-Erlang distribution. The authors give the explicit closed-form expression for the joint Laplace transform of the first passage time and the overshoot for the reflected process. Finally, the formula is applied to the ruin problem under the barrier dividend strategy and the pricing of the Russian option. 相似文献
6.
Elliptic PDE-constrained optimal control problems with L1-control cost (L1-EOCP) are considered. To solve L1-EOCP, the primal-dual active set (PDAS) method, which is a special semismooth Newton (SSN) method, used to be a priority. However, in general solving Newton equations is expensive. Motivated by the success of alternating direction method of multipliers (ADMM), we consider extending the ADMM to L1-EOCP. To discretize L1-EOCP, the piecewise linear finite element (FE) is considered. However, different from the finite dimensional l1-norm, the discretized L1-norm does not have a decoupled form. To overcome this difficulty, an effective approach is utilizing nodal quadrature formulas to approximately discretize the L1-norm and L2-norm. It is proved that these approximation steps will not change the order of error estimates. To solve the discretized problem, an inexact heterogeneous ADMM (ihADMM) is proposed. Different from the classical ADMM, the ihADMM adopts two different weighted inner products to define the augmented Lagrangian function in two subproblems, respectively. Benefiting from such different weighted techniques, two subproblems of ihADMM can be efficiently implemented. Furthermore, theoretical results on the global convergence as well as the iteration complexity results o(1/k) for ihADMM are given. In order to obtain more accurate solution, a two-phase strategy is also presented, in which the primal-dual active set (PDAS) method is used as a postprocessor of the ihADMM. Numerical results not only confirm error estimates, but also show that the ihADMM and the two-phase strategy are highly efficient. 相似文献
7.
Lilian I. Plotkin Joseph P. Stains 《Cellular and molecular life sciences : CMLS》2015,72(15):2853-2867
Regulation of bone homeostasis depends on the concerted actions of bone-forming osteoblasts and bone-resorbing osteoclasts, controlled by osteocytes, cells derived from osteoblasts surrounded by bone matrix. The control of differentiation, viability and function of bone cells relies on the presence of connexins. Connexin43 regulates the expression of genes required for osteoblast and osteoclast differentiation directly or by changing the levels of osteocytic genes, and connexin45 may oppose connexin43 actions in osteoblastic cells. Connexin37 is required for osteoclast differentiation and its deletion results in increased bone mass. Less is known on the role of connexins in cartilage, ligaments and tendons. Connexin43, connexin45, connexin32, connexin46 and connexin29 are expressed in chondrocytes, while connexin43 and connexin32 are expressed in ligaments and tendons. Similarly, although the expression of pannexin1, pannexin2 and pannexin3 has been demonstrated in bone and cartilage cells, their function in these tissues is not fully understood. 相似文献
8.
Stanley N. Salthe 《Foundations of Science》2010,15(4):357-367
I distinguish Nature from the World. I also distinguish development from evolution. Development is progressive change and
can be modeled as part of Nature, using a specification hierarchy. I have proposed a ‘canonical developmental trajectory’
of dissipative structures with the stages defined thermodynamically and informationally. I consider some thermodynamic aspects
of the Big Bang, leading to a proposal for reviving final cause. This model imposes a ‘hylozooic’ kind of interpretation upon
Nature, as all emergent features at higher levels would have been vaguely and episodically present primitively in the lower
integrative levels, and were stabilized materially with the developmental emergence of new levels. The specification hierarchy’s
form is that of a tree, with its trunk in its lowest level, and so this hierarchy is appropriate for modeling an expanding
system like the Universe. It is consistent with this model of differentiation during Big Bang development to view emerging
branch tips as having been entrained by multiple finalities because of the top-down integration of the various levels of organization
by the higher levels. 相似文献
9.
This paper defines a new class of generalized type I functions, and obtains Kuhn-Tucker necessary and sufficient conditions
and duality results for constrained optimization problems in the presence of the aforesaid weaker assumptions on the objective
and constraint functions involved in the problem. 相似文献
10.
Lin-Hua Jiang Fatema Mousawi Xuebin Yang Sėbastien Roger 《Cellular and molecular life sciences : CMLS》2017,74(20):3697-3710
The ability of cells to migrate to the destined tissues or lesions is crucial for physiological processes from tissue morphogenesis, homeostasis and immune responses, and also for stem cell-based regenerative medicines. Cytosolic Ca2+ is a primary second messenger in the control and regulation of a wide range of cell functions including cell migration. Extracellular ATP, together with the cognate receptors on the cell surface, ligand-gated ion channel P2X receptors and a subset of G-protein-coupled P2Y receptors, represents common autocrine and/or paracrine Ca2+ signalling mechanisms. The P2X receptor ion channels mediate extracellular Ca2+ influx, whereas stimulation of the P2Y receptors triggers intracellular Ca2+ release from the endoplasmic reticulum (ER), and activation of both type of receptors thus can elevate the cytosolic Ca2+ concentration ([Ca2+]c), albeit with different kinetics and capacity. Reduction in the ER Ca2+ level following the P2Y receptor activation can further induce store-operated Ca2+ entry as a distinct Ca2+ influx pathway that contributes in ATP-induced increase in the [Ca2+]c. Mesenchymal stem cells (MSC) are a group of multipotent stem cells that grow from adult tissues and hold promising applications in tissue engineering and cell-based therapies treating a great and diverse number of diseases. There is increasing evidence to show constitutive or evoked ATP release from stem cells themselves or mature cells in the close vicinity. In this review, we discuss the mechanisms for ATP release and clearance, the receptors and ion channels participating in ATP-induced Ca2+ signalling and the roles of such signalling mechanisms in mediating ATP-induced regulation of MSC migration. 相似文献