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排序方式: 共有151条查询结果,搜索用时 15 毫秒
1.
Sara Ruane Stephen J. Richards John D. McVay Burhan Tjaturadi Keliopas Krey Christopher C. Austin 《Journal of Natural History》2018,52(13-16):917-944
ABSTRACTThe island of New Guinea has been identified as biologically megadiverse but many taxa are still poorly known. This is especially the case for many of the island’s snakes, which by their very nature can be difficult to collect and study. Here we examine the phylogenetic and phylogeographic structure of a poorly studied snake genus, Stegonotus, focusing on the species of New Guinea; until now, Stegonotus has never been examined using modern phylogenetic methods. Using molecular data from 49 individuals representing eight of the ten described species, and including all New Guinea taxa, we estimate a multilocus phylogeny and examine population structure to help identify undescribed taxa. We use morphological data from the corresponding museum vouchered specimens (where available) and also examine additional specimens for taxa not included in the molecular data set to determine morphological differences among putative taxa. We find molecular evidence for four new species of Stegonotus, both morphologically obvious and cryptic, and describe them herein. The recognition of these four species indicates that Stegonotus diversity has been previously underestimated and also suggests that there are likely additional undescribed taxa within the genus. These four taxa increase the number of described species by 40% and further confirm New Guinea as the centre of diversity for the genus.www.zoobank.org/urn:lsid:zoobank.org:pub:9E21390E-3FD4-40EB-9442-31BC92A76B4F 相似文献
2.
Diego Reginensi Patricia Carulla Sara Nocentini Oscar Seira Abel Torres-Espín Andreu Matamoros-Angles Rosalina Gavín María Teresa Moreno-Flores Francisco Wandosell Josep Samitier Xavier Trepat Xavier Navarro José Antonio del Río 《Cellular and molecular life sciences : CMLS》2015,72(14):2719-2737
Olfactory ensheathing cell (OEC) transplantation emerged some years ago as a promising therapeutic strategy to repair injured spinal cord. However, inhibitory molecules are present for long periods of time in lesioned spinal cord, inhibiting both OEC migration and axonal regrowth. Two families of these molecules, chondroitin sulphate proteoglycans (CSPG) and myelin-derived inhibitors (MAIs), are able to trigger inhibitory responses in lesioned axons. Mounting evidence suggests that OEC migration is inhibited by myelin. Here we demonstrate that OEC migration is largely inhibited by CSPGs and that inhibition can be overcome by the bacterial enzyme Chondroitinase ABC. In parallel, we have generated a stable OEC cell line overexpressing the Nogo receptor (NgR) ectodomain to reduce MAI-associated inhibition in vitro and in vivo. Results indicate that engineered cells migrate longer distances than unmodified OECs over myelin or oligodendrocyte-myelin glycoprotein (OMgp)-coated substrates. In addition, they also show improved migration in lesioned spinal cord. Our results provide new insights toward the improvement of the mechanisms of action and optimization of OEC-based cell therapy for spinal cord lesion. 相似文献
3.
4.
Sara B. Seidelmann Janet K. Lighthouse Daniel M. Greif 《Cellular and molecular life sciences : CMLS》2014,71(11):1977-1999
Arteries consist of an inner single layer of endothelial cells surrounded by layers of smooth muscle and an outer adventitia. The majority of vascular developmental studies focus on the construction of endothelial networks through the process of angiogenesis. Although many devastating vascular diseases involve abnormalities in components of the smooth muscle and adventitia (i.e., the vascular wall), the morphogenesis of these layers has received relatively less attention. Here, we briefly review key elements underlying endothelial layer formation and then focus on vascular wall development, specifically on smooth muscle cell origins and differentiation, patterning of the vascular wall, and the role of extracellular matrix and adventitial progenitor cells. Finally, we discuss select human diseases characterized by marked vascular wall abnormalities. We propose that continuing to apply approaches from developmental biology to the study of vascular disease will stimulate important advancements in elucidating disease mechanism and devising novel therapeutic strategies. 相似文献
5.
Tammy Iwasa-Arai Vitor Luz Carvalho Cristiana Silveira Serejo 《Journal of Natural History》2017,51(37-38):2225-2245
6.
Sara Lise Jeppesen 《Systemic Practice and Action Research》2011,24(2):133-146
The aim of this paper is to explore an explicit use of the concept of sustainability within transport planning. This paper
analyses the concept of sustainability based on a practical approach for a sustainable development of Nordhavn, an area of
Copenhagen, exemplifying a complex planning problem. An exploration of the application of the concept of sustainability is
carried out using elements of Soft Systems Methodology (SSM). This approach indicates a need to separate the use of sustainability
considerations regarding the transport planning ‘process’ from the transport planning ‘results’. The two approaches are related
to the planning levels presented by Ulrich (Syst Prac 1(4):415–428, 1988). It was chosen to focus on the understanding of a sustainable transport planning process. This focus is addressed by four
stakeholder groups interviewed based on the ‘ought to’ mode of Critical Systems Heuristics (CSH). Finally an outline of some
of the factors of a sustainable transport planning process is proposed. 相似文献
7.
Jonathan Cools-Lartigue Jonathan Spicer Sara Najmeh Lorenzo Ferri 《Cellular and molecular life sciences : CMLS》2014,71(21):4179-4194
Neutrophils are being increasingly recognized as an important element in tumor progression. They have been shown to exert important effects at nearly every stage of tumor progression with a number of studies demonstrating that their presence is critical to tumor development. Novel aspects of neutrophil biology have recently been elucidated and its contribution to tumorigenesis is only beginning to be appreciated. Neutrophil extracellular traps (NETs) are neutrophil-derived structures composed of DNA decorated with antimicrobial peptides. They have been shown to trap and kill microorganisms, playing a critical role in host defense. However, their contribution to tumor development and metastasis has recently been demonstrated in a number of studies highlighting NETs as a potentially important therapeutic target. Here, studies implicating NETs as facilitators of tumor progression and metastasis are reviewed. In addition, potential mechanisms by which NETs may exert these effects are explored. Finally, the ability to target NETs therapeutically in human neoplastic disease is highlighted. 相似文献
8.
CFTR biogenesis starts with its co-translational insertion into the membrane of endoplasmic reticulum and folding of the cytosolic domains, towards the acquisition of a fully folded compact native structure. Efficiency of this process is assessed by the ER quality control system that allows the exit of folded proteins but targets unfolded/misfolded CFTR to degradation. If allowed to leave the ER, CFTR is modified at the Golgi and reaches the post-Golgi compartments to be delivered to the plasma membrane where it functions as a cAMP- and phosphorylation-regulated chloride/bicarbonate channel. CFTR residence at the membrane is a balance of membrane delivery, endocytosis, and recycling. Several adaptors, motor, and scaffold proteins contribute to the regulation of CFTR stability and are involved in continuously assessing its structure through peripheral quality control systems. Regulation of CFTR biogenesis and traffic (and its dysregulation by mutations, such as the most common F508del) determine its overall activity and thus contribute to the fine modulation of chloride secretion and hydration of epithelial surfaces. This review covers old and recent knowledge on CFTR folding and trafficking from its synthesis to the regulation of its stability at the plasma membrane and highlights how several of these steps can be modulated to promote the rescue of mutant CFTR. 相似文献
9.
Sara 《大众科学.科学研究与实践》2013,(7)
正现今一些人的肠胃比较脆弱,特别是老人和孩子,而一旦食物搭配出现了问题,就容易导致腹泻了夏季炎热,人们经常认为呆在空调房内或开着空调睡觉,腹部很容易受凉,致使肠蠕动增加是导致腹泻的原因,然而,有时候,并不是着凉了,而是你食用了错误的食物搭配。下面,小编为你盘点易致腹泻的食物搭配。葡萄+牛奶葡萄和牛奶不能同食,因为葡萄里含有果酸,会使牛奶中的蛋白质凝固,不仅影响吸收,严重者还会出现腹胀、腹痛、腹泻等症状。因此,应在喝完牛奶1小时后 相似文献
10.
Sara Proietti Alessandra Cucina Russel J. Reiter Mariano Bizzarri 《Cellular and molecular life sciences : CMLS》2013,70(12):2139-2157
Melatonin is involved in many physiological functions and it plays an important role in many pathological processes as well. Melatonin has been shown to reduce the incidence of experimentally induced cancers and can significantly inhibit the growth of some human tumors, namely hormone-dependent cancers. The anticancer effects of melatonin have been observed in breast cancer, both in in vivo with models of chemically induced rat mammary tumors, and in vitro studies on human breast cancer cell lines. Melatonin acts at different physiological levels and its antitumoral properties are supported by a set of complex, different mechanisms of action, involving apoptosis activation, inhibition of proliferation, and cell differentiation. 相似文献