Extracellular matrix components in intestinal development

Intestinal morphogenesis and differentiation are dependent on heterotypic cell interactions between embryonic epithelial cells (endoderm) and stromal cells (mesenchyme). Extracellular matrix molecules represent attractive candidates for regulators of these interactions. The structural and functional diversity of the extracellular matrix as intestinal development proceeds is demonstrated by 1) spatio-temporal specific expression of the classically described constituents, 2) the finding of laminin and collagen IV variants, 3) changes in the ratio of individual constituent chains, and 4) a stage-specific regulation of basement membrane molecule production, in particular by glucocorticoids. The orientation/assembly of these extracellular matrix molecules could direct precise cellular functions through interactions via integrin molecules. The involvement of extracellular matrix, and in particular basement membrane molecules in heterotypic cell interactions leading to epithelial cell differentiation, has been highlighted by the use of experimental models such as cocultures, hybrid intestines and antisense approaches. These models allowed us to conclude that a correct elaboration and assembly of the basement membrane, following close contacts between epithelial and fibroblastic cells, is necessary for the expression of differentiation markers such as digestive enzymes.     

Response of mollusk assemblages from the Luochuan loess section to orbital forcing since the last 250 ka

This note presents a new result of terrestrial mollusk study from the Luochuan loess section since the last 250 ka. A total of 213 samples, taken at intervals of 10 cm in the S₀-L₃ portion, were analyzed for fossil mollusks. Generally, 150–600 individuals were counted in each sample. According to the distribution of mollusk fossil assemblages in the loess section, 11 mollusk fossil zones have been recognized, representing different climatic and ecological conditions. Three main ecological groups were identified according to the temperature and moisture requirements of each taxon. The cold-aridiphilous group shows maxima at about 240–220, 190–182, 150–140 and 74–66 ka BP. The thermo-humidiphilous set has high abundances for at least 6 times in the section at about 246–240, 220–216, 170–158, 92–86, 60–44 and 10 kaBP. Our results show that variations in mollusk ecological groups are related with changes in the Earth orbital parameters at the 41 and 20 ka frequencies. Maxima in thermo-humidiphilous taxa are in phase with accretion intervals of obliquity (41 ka period), reflecting the East Asian summer monsoon with 41 ka period in controlling variations in terrestrial mollusk ecological groups. In addition, maxima in thermohumidiphilous taxa appearing at about 246–240, 220–216, 60 and 10 kaBP, are consistent with procession (20 ka period) maxima, indicating that the procession period also plays an important role in adjusting the ecological pattern of mollusk groups.     

外显生长指数

基于一篇文章所引用的参考文献和该文的被引频次两个维度,提出了衡量该文外显成长度的相对指标.该研究涉及的引用数据及每条参考文献的被引数据均来自网络版科学引文索引(Web of Science),检索日期为2010年4月最后一周.     

The publication-citation matrix and its derived quantities

We give an overview of the main data of a publication-citation matrix. We show how impact factors are defined, and, in particular, point out the difference between the synchronous and the diachronous impact factor. The advantages and disadvantages of using both as tools in research evaluation are discussed.     

论文-引文矩阵及其推导的定量评价指标

对论文－引文矩阵的主要数据进行了分析，分析了影响因子的定义，指出了同时影响因子和历时影响因子的判别，并且讨论了使用两种影响因子进行科研评价的优缺点，建议将历时影响因子作为测度值，与被评价论文的预期影响因子，即学科引文分值进行比较。     

Purification and reconstitution of the calcium release channel from skeletal muscle

The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.     

克劳德·申农:科学家与工程师(英文)

2 0 0 1年初克劳德·申农逝世了 .本文对申农的生平做了总体介绍 .申农是许多科学领域的先驱 :他在开关理论中引入了布尔代数 ,他是通讯理论之父 ,他还做过一些人工智能方面的实验 .这里 ,我们着重介绍他的工作与信息科学的关联 .此外 ,也描述了他对n grams的运用 .最后 ,我们对n grams在信息科学领域的应用做了一般性讨论     

On indexing in the Web of Science and predicting journal impact factor

We discuss what document types account for the calculation of the journal impact factor （JIF） as published in the Journal Citation Reports （JCR）. Based on a brief review of articles discussing how to predict JIFs and taking data differences between the Web of Science （WoS） and the JCR into account, we make our own predictions. Using data by cited-reference searching for Thomson Scientific＇s WoS, we predict 2007 impact factors （1Fs） for several journals, such as Nature, Science, Learned Publishing and some Library and Information Sciences journals. Based on our colleagues＇ experiences we expect our predictions to be lower bounds for the official journal impact factors. We explain why it is useful to derive one＇s own journal impact factor.     

A high-intensity highly coherent soft X-ray femtosecond laser seeded by a high harmonic beam

Synchrotrons have for decades provided invaluable sources of soft X-rays, the application of which has led to significant progress in many areas of science and technology. But future applications of soft X-rays--in structural biology, for example--anticipate the need for pulses with much shorter duration (femtoseconds) and much higher energy (millijoules) than those delivered by synchrotrons. Soft X-ray free-electron lasers should fulfil these requirements but will be limited in number; the pressure on beamtime is therefore likely to be considerable. Laser-driven soft X-ray sources offer a comparatively inexpensive and widely available alternative, but have encountered practical bottlenecks in the quest for high intensities. Here we establish and characterize a soft X-ray laser chain that shows how these bottlenecks can in principle be overcome. By combining the high optical quality available from high-harmonic laser sources (as a seed beam) with a highly energetic soft X-ray laser plasma amplifier, we produce a tabletop soft X-ray femtosecond laser operating at 10 Hz and exhibiting full saturation, high energy, high coherence and full polarization. This technique should be readily applicable on all existing laser-driven soft X-ray facilities.