明清时代的鄱阳商业与商人

文章利用方志与墓志中的商业与商人史料,分析了明清时代鄱阳县本地商业状况与外来商帮构成,以及鄱阳商人的经营行业和商贸地域.透过商人的传记资料,可以看到士人为商人写传,大力肯定商人的志业,商人则高度认同士人所代表的儒学主流价值观;方志为商人立传,商人为桑梓与国家效力,体现的是士商之间、商人与国家和社会之间相得益彰、"美美与共"的良性互动.     

螺栓连接大变形梁非线性振动特性的实验研究

柔性机械臂、大型可展开天线等机械结构的动作精度受运动过程中大变形几何非线性和连接处接触非线性的影响十分显著。以含螺栓连接结构的大变形梁作为研究对象，针对动力学建模和振动特性开展了实验研究，通过数值计算验证了实验发现的非线性振动特性。搭建了含螺栓连接柔性大变形梁的实验台架，开展了敲击和正弦激振的实验测试。实验结果表明，螺栓连接的柔性梁较连续梁的（无螺栓连接）模态频率降低，阻尼增加，反映出随着激励能量增大，模态频率降低的非线性模态特征。改变螺栓连接位置会显著影响结构的模态频率，其变化规律可由求解线性矩阵特征值定性反映。     

烟支硬度检测结果影响因素分析

为探究烟支硬度检测结果的影响因素,对烟支物理指标检测方案进行优化,提升卷烟质量监督水平.本试验以3类卷烟泰山(东方)为试验材料,分别设计不同检测方案、挡烟板位置、预压时间、压缩时间、压缩速度、环境湿度、贮存时间来对烟支硬度进行测定.烟支检测全项时硬度明显高于单独检测出的硬度;随挡烟板位置的增加,烟支硬度检测值先下降再上升;预压时间、压缩速度对烟支硬度检测结果影响不显著;不同的测试环境湿度会引起烟支水分变化,进而导致烟支硬度检测值产生变化;1个月内硬度不会发生明显变化,但是随着贮存时间延长而增长.应适当优化烟支物理指标检测顺序或方案,设置挡烟板位置为距离接嘴端55 mm,降低测定环境湿度为60％±2％,减少烟支贮存时间或控制贮存环境湿度,及时维护测定设备,以提升质量监督水平.     

Side-Channel Attacks in a Real Scenario

Existing Side-Channel Attacks(SCAs) have several limitations and, rather than to be real attack methods,can only be considered to be security evaluation methods. Their limitations are mainly related to the sampling conditions, such as the trigger signal embedded in the source code of the encryption device, and the acquisition device that serves as the encryption-device controller. Apart from it being very difficult for an attacker to add a trigger into the original design before making an attack or to control the encryption device, there is a big gap in the capacity of existing SCAs to pose real threats to cipher devices. In this paper, we propose a new method, the sliding window SCA(SW-SCA), which can be applied in scenarios in which the acquisition device is independent of the encryption device and for which the encryption source code requires no trigger signal or modification. First,we describe the main issues in existing SCAs, then we theoretically analyze the effectiveness and complexity of our proposed SW-SCA —a method that can incorporate a sliding-window mechanism into almost all of the existing non-profiled SCAs. The experimental results for both simulated and physical traces verify the effectiveness of the SW-SCA and the appropriateness of its theoretical complexity.     

双辊薄带连铸低碳微合金钢的铸态组织

采用双辊薄带连铸技术制备了低碳微合金钢薄带，利用OM，SEM和TEM对铸态凝固组织、室温组织、析出及位错进行观察和分析.结果表明:低碳微合金钢铸带的凝固组织中二次枝晶间距约为12~15μm，相对于传统厚板坯和薄板坯连铸，铸带组织得到了明显细化.铸带的原奥氏体晶粒尺寸比较粗大，约为250~410μm，其组织由魏氏铁素体、珠光体和不规则铁素体组成.铸带组织中存在纳米级TiC析出和短棒状的渗碳体.TiC析出没有被薄带连铸的凝固过程及二次冷却过程明显抑制.铸带组织由于铸轧力及二次冷却速率不均匀导致大量位错的产生.     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

适用于混沌密钥分发的新误码协调方法

对于现有的密钥分发中的误码协调方法的复杂性和多次传输的问题，使用倒三角类坐标定位法来解决。将所得裸钥放置于下三角矩阵中，三边分别进行奇偶比较并互相传输计算结果，以达到定位错误比特位的目的。使用互注入光反馈激光器产生相关性高的混沌态来提取裸钥，通过该协调方法，最终可以达到10－8～10－10量级的误码率。通过该方法可以简单、有效地删除裸钥中的误码，满足现实通信对误码率的容忍度。     

结肠息肉内镜下治疗的体会

目的:探讨结肠息肉内镜下治疗的各种方法及效果.方法:通过肠镜检查8 024例确诊的各种形态、大小息肉1 326例共1 637颗,对于不同大小、形态的息肉,采用单一和联合的内镜治疗.结果:1 326例结肠息肉内镜治疗1 637颗,其中有4例因基底癌变转外科治疗,发生迟发性出血9例,再次内镜下止血成功;穿孔2例,1例钛夹修补成功,1例钛夹修补失败转外科治疗,并发症发生率为0.82%.结论:结肠息肉内镜下治疗是一种安全有效的方法.     

济宁市农村社会养老服务供需的实证研究

本文通过抽样调研,对济宁市农村人口老龄化现状以及社会养老服务供需进行分析,从而对实现该地区农村社会养老服务供需均衡提出相应对策,以促进济宁市养老保障事业发展.