血管内皮生长因子结合可降解壳聚糖治疗大鼠心肌梗塞的研究

摘要:目的 研 究 血 管 内 皮 生 长 因 子 ( vascular endothelial growth factor, VEGF ) 结 合 可 降 解 壳 聚 糖 ( degradablechitosan,DC)对心肌梗塞大鼠的治疗作用。 方法 将 32 只 SD 大鼠随机分为假手术组、模型组、VEGF 组和 VEGF+ DC 组,每组 8 只。 4 组大鼠均采用结扎冠状动脉左前降支的方法进行造模,其中假手术组只穿线不结扎。 造模后, 向模型组大鼠心肌注射 100 μL 生理盐水,VEGF 组大鼠于同一位置注射同体积 VEGF 溶液,VEGF+DC 组大鼠注射 VEGF+DC 溶液。 造模 4 周 后,对 所 有 实 验 大 鼠 进 行 超 声 心 功 能 检 测,考 察 左 心 室 收 缩 期 及 舒 张 期 前 壁 厚 度( LVAW;s 和 LVAW;d) 、左心室收缩期及舒张期内径( LVID;s 和 LVID;d) 、左心室收缩期及舒张期容积( LV Vol;s 和 LV Vol;d) 、左室射血分数( EF% )及短轴缩短率( FS% ) ,血流动力学考察左室舒张末压( EDP ) 和等容收缩期及 舒张期左心室内压力上升最大速率( + dp / dt 和 - dp / dt) ,计算左心室指数( LVM / BW) 并对心肌进行苏木素-伊红 ( HE)染色观察各组实验大鼠心肌病理变化。 结果 VEGF 组和 VEGF+DC 组大鼠的心肌梗塞均得到有效改善,其 中 VEGF+DC 组的改善作用更加显著。 结论 VEGF 结合 DC 对心肌梗塞大鼠的心功能具有改善作用,具有一定的治疗作用。     

Maxwell's role in turning the concept of model into the methodology of modeling

This is a contribution towards a history and philosophy of modeling in its early stages in electromagnetism. In 1873, James Clerk Maxwell (1831–1879) hinted at the methodology of modeling at the end of his Treatise on Electricity and Magnetism. We focus on Maxwell's impact on physicists who immediately followed him, specifically Oliver Lodge (1851–1940) and George Francis FitzGerald (1851–1901). We begin with the role that the scientific concept of model played in the late nineteenth century, as assessed by Ludwig Boltzmann (1844–1906). We then discuss the role of hypothesis as a methodology, the appeal to (dynamical) illustration, and the way Maxwell applied model and working model in his studies of electromagnetism. We show that for Maxwell these key terms were kept distinct, but Lodge did not maintain these distinctions and, in this regard, FitzGerald followed Lodge. Notwithstanding Lodge's influence, Fitzgerald modified Maxwell's theory based on the mechanical model he designed, thereby implicitly taking the first step towards modeling. This methodology consists in drawing consequences from the (mechanical) model to the (electrodynamic) theory and modifying the latter in light of the functioning of the former. At the core of our argument is the thesis that it was a methodological novelty to move from the concept of model to the methodology of modeling. The introduction of modeling as a new methodology into physics in the late nineteenth century was a major event which deserves proper recognition.     

数字化转型提升通用航空企业竞争力的机理研究 ——基于21家企业的扎根分析

通用航空产业是我国的新兴产业,尚未形成较大的规模和市场,是数字化转型发展的重点产业.运用因子分析法对21家通用航空上市企业竞争力进行了评价,结果表明其竞争力水平不强.运用扎根分析法研究了其中10家竞争力较强企业的数字化转型形式,得到4种类型:数字化生产、数字化研发平台、产品智能化、产业智能化;以4种数字化转型的先进企业为代表分别归纳出通航企业竞争力的影响机理,并以未实施数字化转型的企业进行了反证,提出了数字化转型发展提升通用航空企业竞争力的路径.     

基于差异信息量的多源数据融合方法

D-S证据理论可应用于多源数据融合领域，但在处理高度冲突的证据时，可能会出现反直觉的结果.为解决这一问题，本文提出了差异信息量的概念及融合方法.首先，通过信息熵表明证据的相对重要性，采用散度获取证据可信度.然后利用证据可信度优化证据差异度以得到差异信息量，经过计算获取数据的最终权重，并将其作为D-S证据理论中的基本概率分配进行决策.在处理冲突证据、一致证据及不同数量证据等方面的数据融合问题时与其他方法对比，所提方法收敛更快，准确度更高.故障诊断的应用实例表明，所提方法的不确定性更小，优于现存的其他方法.     

Controllability of Quantum Systems with SU(1, 1) Dynamical Symmetry

This paper presents sufficient and necessary conditions for the propagator controllability of a class of infinite-dimensional quantum systems with SU(1, 1) dynamical symmetry through the isomorphic mapping to the non-unitary representation of SU(1, 1). The authors prove that the elliptic condition of the total Hamiltonian is both necessary and sufficient for the controllability and strong controllability. The obtained results can be also extended to control systems with SO(2, 1) dynamical symmetry.     

Little-known and phylogenetically obscure South African estuarine microgastropods (Mollusca: Truncatelloidea) as living animals

Areas of the Knysna estuarine bay in the Western Cape are dominated by three endemic South African truncatelloid microgastropods, temporarily known as ‘Hydrobia’ knysnaensis (Krauss), ‘Assiminea’ capensis (Sowerby) and ‘Assiminea’ globulus Connolly. Although first described 80–170 years ago and present in abundance (up to 100,000 m^?2), they remain surrounded by confusion and still await taxonomic assignment, largely because they appear most atypical members of their groups by virtue of anatomy and/or biogeography and/or habitat. This study contributes in-life perspectives to morphological and phylogenetic analyses known to be on-going. At Knysna, they are syntopic: at least two occurring in >85% and all three in >40% of individual 0.0026 m² samples from their region of dominance. Nevertheless, they tend to greater abundance in divergent microhabitats; ‘A.’ globulus dominating higher tidal levels, and ‘A.’ capensis and ‘Hydrobia’ lower ones; the former especially unvegetated sediment, the latter, if anything, seagrass. Interspecific feeding interactions appear unlikely to be responsible for these patterns, other evidence suggesting that all are maintained below carrying capacity. Field biology of ‘H.’ knysnaensis generally appears equivalent to that of northern-hemisphere intertidal hydrobiids and that of ‘A.’ globulus is typically assimineid, albeit at atypically low shore height. Unlike assimineids, however, ‘A.’ capensis is truly aquatic. The success of these truncatelloids in unusual circumstances may be consequent on the absence from South Africa of other microgastropod groups that fill their niches elsewhere in the southern hemisphere.     

我国高校图书馆的微博发展状况和读者服务创新

在网络自媒体时代,越来越多的高校图书馆利用微博拓展其服务,而微博的许多优点也使其适用于图书馆的文献信息传递和读者服务。通过对新浪微博的数据调查,阐述了近年来高校图书馆微博的发展状况,探讨了微博给高校图书馆读者服务带来的创新,分析了微博的特点及其在图书馆服务中的适用性,提出了高校图书馆利用微博创新读者服务的具体对策。     

从北京APEC会议看重大活动档案的收集管理

阐述了重大活动档案收集管理的意义,介绍了2014年11月北京APEC会议档案收集管理情况,提出了加强重大活动档案收集管理的方法。     

基于老厂房改造的景观规划设计

随着城市化高速发展，老厂房再利用的问题日益急迫.上海是中国近代工业起源地,也是率先着手对彰显城市文脉的工业遗产进行调查和保护的历史文化名城.本文以上海典型案例入手，分析了具有代表性的老厂房改造的项目特点，并在此基础上，对常州大成三厂这一民国时期的纺织业遗留地块进行改造设计手法进行介绍，从设计理念、设计内容和节点设计3个方面，体现了文化传承和生态技术相融合理念.