卡默勒现象意识的幻觉主义分析

卡默勒的幻觉主义理论是现象意识分析中一种不同的声音。其幻觉主义理论认为:现象意识是一个幻觉；可基于相似性理论来解释现象意识的机制，指出现象意识就是外部物理性质经模块处理的结果，其处理过程遵循表象原则、接受喜好原则、配置原则和个例化原则；现象意识的幻觉元是解释现象意识为何强烈的问题。幻觉主义理论为现象意识的分析提供了一个新的思路，但也存在着如特殊心理模块等的理论缺陷。     

石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能的疗效观察

目的 评价石杉碱甲片联合丁苯酞软胶囊对阿尔茨海默病患者认知功能的临床疗效.方法 将100例轻度阿尔茨海默病(Alzheimer's disease,AD)患者随机分为石杉碱甲片联合丁苯酞软胶囊组(治疗组)及单独应用石杉碱甲组(对照组).治疗前及治疗90 d后分别评价两组患者简易智力状态检查(Mini-mental State Examination,MMSE)量表、事件诱发电位P300潜伏期、波幅及不良反应.结果 石杉碱甲片联合丁苯酞软胶囊组治疗90 d后,MMSE评分和P300潜伏期、波幅与治疗前比较差异均具有统计学意义(P<0.05);与单独应用石杉碱甲组比较差异具有统计学意义(P<0.05).结论 石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能有明显改善,且优于单独应用石杉碱甲片组.     

考虑保障装备可用度的舰载机作业调度优化

为了在保证较高水平的保障可用度前提下提高舰载机出动效率, 提出一种支持可用度约束的统计优化模型及其对应的启发式求解算法。能够同时生成舰载机的保障作业调度方案和保障装备计划性维护的时间安排, 并通过基于仿真的优化方式, 在启发算法的适应度评价中增加对视情维修和事后维修的仿真, 提高了舰载机作业调度方案的鲁棒性。仿真结果表明，所提算法能够提供一个稳定可靠的基准调度方案, 避免不必要的重调度。     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

Uncoupled PID Control of Coupled Multi-Agent Nonlinear Uncertain systems

In this paper, PID (proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimensional nonlinear uncertain dynamical system, which only has access to its own tracking error information and does not need to communicate with others. This paper will show that a 3-dimensional manifold can be constructed based on the information about the Lipschitz constants of the system nonlinear dynamics, such that whenever the three parameters of each PID controller are chosen from the manifold, the whole multi-agent system can be stabilized globally and the tracking error of each agent approaches to zero asymptotically. For a class of coupled first-order multi-agent nonlinear uncertain systems, a PI controller will be designed to stabilize the whole system.     

随机和认知混合不确定系统的全局灵敏度分析方法

为计算具有随机不确定性和认知不确定性的混合不确定系统灵敏度,提出一种基于证据理论和条件概率理论的全局灵敏度分析方法.用证据理论对认知不确定性变量进行表征,并提出两种基于证据理论的随机采样方法,包括一次随机抽样法和二次随机抽样法.运用条件概率理论,提出存在认知不确定性条件下混合不确定系统的Sobol'全局灵敏度指标,经过理论推导给出一阶灵敏度及总灵敏度的计算公式,并设置单循环的拟蒙特卡罗方法实现灵敏度的近似数值计算.开发了灵敏度分析程序,并给出了典型应用实例.实例表明,新方法的分析结果正确,计算工作量可控.     

A Novel Routing Method for Social Delay-Tolerant Networks

The lack of continuous connectivity and a complete path from source to destination makes node communication quite difficult in Delay-Tolerant Networks(DTNs). Most studies focus on routing problems in idealized network environments without considering social properties. Communication devices are carried by individuals in many DTNs; therefore, DTNs are unique social networks to some extent. To design efficient routing protocols for DTNs, it is important to analyze their social properties. In this paper, a more accurate and comprehensive metric for detecting the quality of the relationships between nodes is proposed, by considering the contact time, contact frequency, and contact regularity. An overlapping hierarchical community detection method is designed based on this new metric, and a tree structure is built. Furthermore, we exploit the overlapping community structure and the tree structure to provide message-forwarding paths from the source node to the destination node.The simulation results show that our Routing method based on Overlapping hierarchical Community Detection(ROCD) achieves better delivery rate than SimBet and Bubble Rap, the classic routing protocols, without affecting the average delay.     

某电解铅厂周边农田土壤和玉米中铅污染评价及同位素溯源研究

为探究铅在土壤-玉米-大气中的迁移转化行为,以某电解铅厂周边农田土壤和玉米为研究对象,采集距排烟口50 m、110 m、300 m、500 m、700 m、900 m和3 000 m处的土壤和玉米样品,利用原子吸收光谱仪(AAS)和电感耦合等离子体质谱仪(ICP-MS)分别测定土壤、玉米和大气样品的铅含量和同位素比值。结果表明:电解铅厂周边的玉米均受到铅的污染,玉米根中的铅主要来自土壤,籽粒中的铅很有可能大部分来自大气,少部分来自土壤,茎中的铅很可能来自土壤而不是叶面传输;籽粒中的铅与叶片中的铅具有显著的相关关系(P0.01),相关方程为y=-0.0002x~2+0.0461x-0.4643,R=0.966 7。     

R型半胱氨酸体系电荷转移百分数的理论计算

采用密度泛函理论中的CAM-B3LYP方法, 在6-31G(d)基组水平上优化气相条件下R型半胱氨酸(R-Cys)分子的几何构型, 理论研究电子激发过程中R-Cys体系片段间的电荷转移特征, 并基于弛豫与非弛豫激发态密度计算片段间的电荷转移百分数. 结果表明: 对于SH片段, S0到S3的电荷转移百分数为57.96%； 对于COOH片段, S0到S1~S5各激发态的电荷转移百分数均为负值, 二者电荷转移的定性结果一致； 对于NH2片段, S0到S1和S4的电荷转移百分数分别为6.98%和31.45%.