Finite element models and molecular dynamic simulations for studying the response of mast cell under mechanical activation

In micropipette aspiration experiment, increasing mechanical stress applied to cell membrane induced degranulation of mast cell as well as a current that could be inhibited by an inhibitor, which is specific for the transient receptor potential vanilloid （TRPVs） channels. To determine the sensitivity of TRPVs to membrane strain and tension, and to gain new insights into the activation mechanism of TRPVs, finite element models of mast cell and molecular dynamic simulations of human aquaporin-1 are presented. During the finite element simulations, the cell membrane sustained to micropipette aspiration was simulated, and the strain distribution along membrane thickness direction was obtained. Besides, combining the finite element models of osteoblast aspirated into micro- pipette and other compared models, we examined the relationship between cell mechanical stimulations and mechanical attributes and presented a new perspective to determine the cell equivalent elastic modulus. Consid- ering the indetermination of TRPV crystal structure, human aquaporin-1, one kind of the channel membrane proteins, substituting for TRPV, has been studied with molecular dynamic （MD） simulations, under different external lateral tensions which have been obtained in mast cell finite ele- ment simulations, to investigate the mechanical stimulation effects on the membrane channels. The simulations show that human aquaporin-1 undergoes significant conforma- tional change and expands in accordance with lateraltension, which not only confirms the tendency of the pre- vious electrophysiological experiments but also leads us to a better understanding of TRPVs. The multi-scale study combining finite element simulation and MD simulation is a significant breakthrough in the field of mechanical mechanism in cell system.     

振动过程的数值模拟实验

利用数学问题的通用软件包Mathematica，设计出一组新颖的数值模拟实验，可以有效地帮助学生通过自己探索来了解和掌握振动过程的规律，促进学生创新精神和实际能力的培养。     

Some functions with low differential uniformity

We study the functions with low differential uniformity, and concentrates mainly on the properties of perfect nonlinear (PN) functions, including the properties of the derivative of the components of those functions. Some sufficient and necessary conditions have been explored to judge when a function is a PN function. These conditions may be useful in constructing new PN functions. We also construct some functions with differential 4-uniformity that have rarely been studied in the literature. Some of the constructed functions with differential 4-uniformity have high nonlinearity as well. Finally, a class of functions with differential 4-uniformity which are not extended affine equivalent to any power functions are constructed.     

基于网络划分的SDN分布式控制器部署

针对大规模SDN （software defined networking）网络中分布式控制器部署问题,以优化网络弹性和可靠性为目标,提出两阶段控制器部署算法（TSCP,two-stage controller placement）：利用节点相似度划分控制域,使得控制域内设备之间的连通性强、连接紧密,增强控制域的网络弹性;选择控制路径平均失效率最小的控制器集合作为控制器部署,提高网络可靠性。通过约束控制域的规模和设备（交换机或控制器）之间传播时延,使控制域的交换机个数均衡,控制器的部署合理。通过定义性能指标,实验对比GCP算法、K*-means算法,结果表明TSCP算法可以优化控制域的规模,均衡控制域的交换机个数,减少控制器个数,网络弹性和可靠性均表现较好。     

可逆多分子饱和反应动力系统的极限环及其数值模拟

应用微分方程定性理论研究了一类具有2重饱和反应速度的生物化学反应动力系统,得到了关于存在唯一极限环的显著不同的参数区域,并用深度优先搜索算法编程进行了计算机数值模拟,发现其存在Hopf分支现象.     

CAPP 开发工具工艺决策建模的研究

工艺决策建模是ＣＡＰＰ开发工具的研究难点，亦是开发工具走向实用化和商品化的瓶颈所在。这里提出了一种决策建模的数学工具——层次分析法（ＡＨＰ），可将复杂的工艺决策问题进行分解、判断和综合，并采用定性与定量相结合的统一处理方式来解决难以用数学模型定量描述的工艺决策的通用化建模问题。因此，采用一般方法难以描述的通用工艺决策建模问题，转而采用ＡＨＰ法则能比较容易地满足不同制造企业的工艺设计需求。ＡＨＰ法大大提高了系统的性能和适应性。     

稻纵卷叶螟人工饲料的研究

 以稻纵卷叶螟为研究对象,按不同配方配制了6种人工饲料分别用来饲养稻纵卷叶螟,以筛选出适合饲养稻纵卷叶螟的人工饲料。结果表明,在温度为24~26 ℃,相对湿度大于80%,光照条件大于14 h的条件下,其中饲料D、E、F饲养稻纵卷叶螟二龄幼虫只能完成二龄发育,少数幼虫存活到三龄或三龄以上;饲料C饲养稻纵卷叶螟二龄幼虫也只能完成三龄发育;而饲料A和B饲养的稻纵卷叶螟二龄幼虫能完成整个世代发育,存活率分别为26.17%和36.40%,接近对照组新鲜水稻叶饲养的存活率36.67%,且蛹质量和新鲜水稻叶饲养的幼虫没有显著差异,但与对照相比,幼虫历期延长4~6 d、化蛹率下降8%~9%、羽化率下降11%~12%。     

斜纹夜蛾前胸腺的生长发育研究

 通过解剖观察4龄至蛹期斜纹夜蛾前胸腺,对其形态特点和生长发育规律进行了研究,主要结果如下：发现斜纹夜蛾前胸腺由53个左右的圆形或椭圆型细胞成串组成,Y型,成对,外围包裹一层透明鞘膜,位于胸部第一气门的气管丛内;在斜纹夜蛾4龄到蛹期的发育过程中,前胸腺不发生有丝分裂,细胞数量基本恒定;前胸腺细胞直径在幼虫发育期间不断增大,斜纹夜蛾幼虫在4龄第1天的前胸腺直径为(28.80±0.47) μm,而到了6龄末期,则增加到(92.22±2.43) μm;幼虫期的斜纹夜蛾前胸腺细胞直径和虫体体质量呈显著相关,r=0.826,P=0.000,拟合曲线方程为Y=82.1X ^0.263;此外,幼虫期的斜纹夜蛾前胸腺细胞直径和虫体体长也呈现出显著相关,r=0.886,P=0.000,拟合曲线方程： Y=e^{(4.781-1.863/Z)}。     

Parallel Mechanisms with Two or Three Degrees of Freedom

Parallel manipulators for the machine tool industry have been studied extensively for various industrial applications. However, limited useful workspace areas, the poor mobility, and design difficulties of more complex parallel manipulators have led to more interest in parallel manipulators with less than six degrees of freedom (DoFs). Several parallel mechanisms with various numbers and types of degrees of freedom are described in this paper, which can be used in parallel kinematics machines, motion simulators, and industrial robots.     

Dimensional Synthesis Design of Novel Parallel Machine Tool

IntroductionIn recent years,the kinematics design theory ofparallel machine tools(PMT) has been attractingmuch attention from industry and researchcommunities[1,2 ] . The dimensional design is oneimportant part of the PMT kinematics designtheory.　 The approaches in previous work on dimensionaldesign of PMT may be classified into twocategories. One category is local optimal designwhich focuses on finding a family of dimensionalparameters generating an isotropic configuration,that is,a conf…