CKMM基因A/G多态性与耐力、力量速度、混合型运动能力关联性的Meta分析

为探索肌型肌酸激酶(muscle-specific creatine kinase,CKMM)基因A/G单核苷酸多态性与耐力、力量速度、混合型运动能力的关联性,通过检索超星医学在线、万方数据库、维普数据库、中国生物医学文献服务系统、中国知网(CNKI)、中国科学引文数据库(CSCD)、EBSCO数据库、PubMed、Science Direct及Web of Science中CKMM基因A/G多态性与耐力、力量速度、混合型运动能力关联性的相关研究,采用Review Manager 5.3对纳入研究进行荟萃分析(Meta-analysis).结果表明:耐力运动员CKMM基因多态性与耐力运动能力、速度力量及混合型项目运动能力不存在显著关联(P>0.05).根据人种进行亚组分析发现,亚洲及欧洲人群CKMM基因A/G多态性等位基因、显性基因及杂合子模型与耐力运动能力均存在显著关联(P<0.05);亚洲优秀耐力运动员表现为G等位基因增加,欧洲优秀耐力运动员表现为A等位基因增加.由此可见,CKMM基因A/G多态性可作为亚洲及欧洲耐力运动员选拔指标,但应考虑不同种族人群A:G等位基因差异.     

阳极修饰对微生物燃料电池性能的影响

利用PW12/rGO复合材料负载于碳布表面制得PW12/rGO修饰阳极并构建单室空气阴极微生物燃料电池(microbial fuel cells,MFC),考察了PW12/rGO修饰阳极对MFC产电和高氯酸盐(ClO4-)还原性能的影响,并通过对阳极表面形态及其电化学特性的分析,探讨了PW12/rGO修饰阳极改善MFC产电性能的机理.结果 表明,当ClO4-浓度为700 mg/L时,PW12/rGO修饰阳极MFC的最大输出电压和ClO4-平均去除速率分别为200.18 mV和1.15 kg/(m3·d),分别是空白阳极MFC的4.4倍和1.06倍;扫描电镜(SEM)表征显示,PW12/rGO修饰阳极表面附着的微生物量远高于空白阳极;Tafel曲线、循环伏安曲线(CV)和交流阻抗谱(EIS)测试表明,PW12/rGO修饰阳极较空白阳极具有更高的交换电流密度、CV电活性面积以及更低的电荷转移电阻.PW12/rGO修饰阳极提高了阳极电子产量和电子传递速率,进而改善了MFC的产电性能.     

Predictive Event-Triggered Control for Disturbanced Wireless Networked Control Systems

The control and scheduling for wireless networked control system with packet dropout and disturbance are investigated. A prediction based event triggered control is proposed to reduce data transmissions while preserving the robustness against external disturbance. First, a trigger threshold is especially designed to maintain the difference of the estimated and actual states below a proper boundary when system suffers from packet dropout. Then a predictive controller is designed to compensate for packet dropouts by utilizing the packet-based control approach. The sufficient conditions to ensure the closed-loop system being uniformly ultimately bounded are derived, with consequently the controller gain method. Numerical examples illustrate the effectiveness of the proposed approach.     

孕早期睡眠时长与午睡频次对妊娠糖尿病的影响

目的探讨孕早期睡眠时长和午睡频次对妊娠糖尿病(GDM)的影响。方法采用病例对照研究设计,选取2018年4月至2019年5月在安徽省妇幼保健院、吉安市妇幼保健院产检的孕妇作为研究对象。通过问卷调查收集研究对象的睡眠和午睡等信息,GDM的诊断来自孕中期常规口服葡萄糖耐量试验结果。结果共纳入500名研究对象,其中病例组196人,对照组304人。多元Logistic回归分析结果显示,与睡眠时长7～8.9 h/晚相比,睡眠7、9～9.9、≥10 h/晚的孕妇发生GDM的风险均显著上升;与午睡频次≤5 d/周相比,5 d/周的孕妇发生GDM的风险更高。相比孕早期午睡频率≤5 d/周的孕妇,孕早期睡眠时长不足(7 h/晚)对GDM的影响在午睡频率5 d/周的孕妇中更弱,交互作用具有统计学意义(P=0.002)。结论孕早期睡眠时长、午睡频次均与GDM发病相关,且二者在GDM的发生中存在交互作用。     

基于知识图谱的核电设备健康管理知识建模与分析

随着信息技术发展,设备健康数据与知识图谱技术结合为设备健康发展带来新的发展机遇,知识图谱利用其多种特异性优势,使企业系统中积累的海量设备维修数据得到有效整合利用.本文提出基于知识图谱的核电设备健康管理知识建模与分析方法,并根据实体关系模型构建维修知识图谱本体框架,同时基于核电企业实际的维修工单数据,从统计分析和关联分析两方面取得良好的实践效果.研究结果表明,知识图谱能够在设备维修知识的集成上解决传统的数据孤岛问题,同时能基于故障的可视化分析为维修人员和管理人员提供决策和知识支持.     

Impact of the RMB Joining in the SDR Basket on Its Internationalization from the Perspective of Risk Spillover

For evaluating the influence of the Chinese renminbi(RMB) joining in the special drawing right(SDR) basket on RMB's internationalization, the authors systemically study the risk spillover networks and examine the dynamic relationship of exchange rates among the SDR currencies including the US dollar(USD), European Union euro(EUR), Japanese yen(JPY) and British pound(GBP).The empirical results demonstrate that the USD takes a dominant position and holds the biggest risk spillover to other currencies, and the RMB's inclusion to the SDR basket makes the risk spillover to get average, giving rise to the SDR currency system more stable to a certain degree. The inclusion of the RMB in the SDR not only can reduce the systematic risk of the SDR, but also has a certain impact on the international exchange rate markets. Nowadays, in front of the growing trade friction, more such researches could help to effectively deal with the currency disputes.     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

Uncoupled PID Control of Coupled Multi-Agent Nonlinear Uncertain systems

In this paper, PID (proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimensional nonlinear uncertain dynamical system, which only has access to its own tracking error information and does not need to communicate with others. This paper will show that a 3-dimensional manifold can be constructed based on the information about the Lipschitz constants of the system nonlinear dynamics, such that whenever the three parameters of each PID controller are chosen from the manifold, the whole multi-agent system can be stabilized globally and the tracking error of each agent approaches to zero asymptotically. For a class of coupled first-order multi-agent nonlinear uncertain systems, a PI controller will be designed to stabilize the whole system.     

A method for recovery of iron,titanium, and vanadium from vanadium-bearing titanomagnetite

An innovative method for recovering valuable elements from vanadium-bearing titanomagnetite is proposed. This method involves two procedures: low-temperature roasting of vanadium-bearing titanomagnetite and water leaching of roasting slag. During the roasting process, the reduction of iron oxides to metallic iron, the sodium oxidation of vanadium oxides to water-soluble sodium vanadate, and the smelting separation of metallic iron and slag were accomplished simultaneously. Optimal roasting conditions for iron/slag separation were achieved with a mixture thickness of 42.5 mm, a roasting temperature of 1200°C, a residence time of 2 h, a molar ratio of C/O of 1.7, and a sodium carbonate addition of 70 wt%, as well as with the use of anthracite as a reductant. Under the optimal conditions, 93.67% iron from the raw ore was recovered in the form of iron nugget with 95.44% iron grade. After a water leaching process, 85.61% of the vanadium from the roasting slag was leached, confirming the sodium oxidation of most of the vanadium oxides to water-soluble sodium vanadate during the roasting process. The total recoveries of iron, vanadium, and titanium were 93.67%, 72.68%, and 99.72%, respectively.     

A Novel Routing Method for Social Delay-Tolerant Networks

The lack of continuous connectivity and a complete path from source to destination makes node communication quite difficult in Delay-Tolerant Networks(DTNs). Most studies focus on routing problems in idealized network environments without considering social properties. Communication devices are carried by individuals in many DTNs; therefore, DTNs are unique social networks to some extent. To design efficient routing protocols for DTNs, it is important to analyze their social properties. In this paper, a more accurate and comprehensive metric for detecting the quality of the relationships between nodes is proposed, by considering the contact time, contact frequency, and contact regularity. An overlapping hierarchical community detection method is designed based on this new metric, and a tree structure is built. Furthermore, we exploit the overlapping community structure and the tree structure to provide message-forwarding paths from the source node to the destination node.The simulation results show that our Routing method based on Overlapping hierarchical Community Detection(ROCD) achieves better delivery rate than SimBet and Bubble Rap, the classic routing protocols, without affecting the average delay.