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针对多模型对象控制系统,基于遗传算法对PID控制参数进行寻优,分别建立不同工况下的模型,提出了以不同模型下的ITAE(时间乘以误差绝对值积分)性能指标加权和作为遗传算法目标函数的方法,寻优出一组最佳的PID控制参数,使得该参数在不同的对象模型下均表现出良好的调节品质,具有一定的实用价值。  相似文献   
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研究表明HIV-1包膜蛋白gp120上的V3环在病毒结合到靶细胞的过程中起着重要的作用.这个区域中的几个氨基酸残基与gp120同辅受体的结合相关联.在HIV-1感染过程的早期,V3环在患者体内诱导针对HIV病毒的抗体应答,并被确定为主要中和决定簇.一些针对V3环的抗体具有广泛的中和活性.但是,V3环是HIV包膜蛋白的一个高变区,发生着广泛的变异.综述了V3环的结构特征和变异以及生物学功能,并对V3环的免疫反应进行了探讨.  相似文献   
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介绍了以Controller Link网络为控制级和以工控机为管理级组成的两级控制网络,以及Controller Link网络的数据链接和网络参数设置,给出了上位机数据链接通信,并用VB6实现了与工控机的通信.  相似文献   
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卧式喷淋塔技术是北京科技大学环境中心开发的一种新型烟气脱硫系统工艺,在某些方面克服了立式喷淋塔的缺点,具有脱硫效率高、压力损失小、运行成本低、易检修等特点.但在实际工程中仍然需要进一步的改进.为了研究不同喷淋的布置格局对卧式喷淋塔的内部流场的影响,构建了卧式喷淋塔物理模型,采用Icem软件划分网格,利用Fluent软件数值模拟计算.模拟中选择k-ε湍流模型及随机轨道模型,数值模拟计算采用SIMPLE算法.模拟结果表明:双层喷淋设置时喷雾锥角为90°,上部喷淋高度为距顶部0.9 m,下部喷淋高度为距顶部2.4 m,喷淋层间距为1.5 m时,有效的减少脱硫塔压力损失,降低能耗,塔内吸收区烟气流动的速度均匀,增大了气液接触的频率.烟气的温度适宜于气液反应.总体上提高了烟气的脱硫效率,为实际工程的设计和应用提供指导.  相似文献   
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自动化专业实验教学改革方法与对策   总被引:1,自引:0,他引:1  
刘波  田海军  王恭 《科技信息》2009,(33):159-160
实验教学是高等学校创新教育的一个重要环节,是培养学生设计实验和分析、处理数据的能力,掌握专业常用的实验技术和必备专业技能的必要途径和手段。本文从改革实验教学,培养创新能力的角度出发,分析了当前高校自动化专业实验教学的现状及存在的问题,对自动化专业的实验教学体系、实验教学方式、实验教学内容提出了改革与对策。  相似文献   
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A seven-amino acid epitope GPGRAFY at the tip of the V3 loop in HIV-1 gp120 is the principal neutralizing epitope, and a subset of anti-V3 antibodies specific for this epitope shows a broad range of neutralizing activity. GPGRAFY-epitope-specific neutralizing antibodies were produced using predefined GPGRAFY-epitope-specific peptides instead of a natural or recombinant gp120 bearing this epitope. All six monoclonal antibodies (mAbs) could recognize the GPGRAFY-epitope on peptides and two of the antibodies, 9D8 and 2D7, could recognize recombinant gp120 in enzymelinked immunosorkentassy (ELISA) assays. In the flow cytometry analysis, the mAbs 9D8 and 2D7 could bind to HIV-Env CHO-WT cells and the specific bindings could be inhibited by the GPGRAFY-epitope peptide, which suggests that these two mAbs could recognize the native envelope protein gp120 expressed on the cell membrane. However, in syncytium assays, none of the mAbs was capable of inhibiting HIV-Env-mediated cell membrane fusion. The different activities for recognizing native HIV-1 gp120 might be associated with different antibody affinities against the epitopes. The development of conformational mimics of the neutralization epitope in the gp120 V3 loop could elicit neutralizing mAbs with high affinity.  相似文献   
7.
田海军 《科技信息》2007,(4):253-254
针对现有过程控制教学的现状、介绍了基于组态王的过程控制综合实验装置。装有组态王工控软件的计算机完成对被控对象的模拟和监控。通过RS-232和通讯模块通讯。实时检测被控对象的温度、压力、液位、流量四个参数,把采集到的数据进行处理和保存,并根据控制要求进行PID运算,运算结果控制执行器动作,执行器为电动调节阀变频器和电动机。并以串级控制系统为例,说明了过程控制系统的组态及实验步骤。  相似文献   
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IntroductionIt has been demonstrated that humanimmunodeficiency virus type1 ( HIV- 1 ) gp41 isinvolved in HIV- 1 entry into the cell. Recentcrystal structure analysis of gp41 revealed that thebinding of gp1 2 0 to CD4and a co- receptor inducesthe conformational changes of gp41 ,resulting inthe exposure of the N- and C- domains and creationof a fusion intermediate and then the fusionprocess[1,2 ] .Itis generally agreed thatthe V3loopof gp1 2 0 plays a major role in the binding of gp1 2 0wit…  相似文献   
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HIV-1 mutation results in immune evasion, which presents a serious challenge for conventional strategies for developing effective vaccines. So far, much experimental evidence indicates that HIV-1 particles in the blood of patients can be cleaned principally by neutralizing antibodies. Based on these facts, we prepared triple combination of epitope-vaccines with the objective of inducing antibodies with predefined multi-epitope-specificity against HW-1. According to the sequences of three neutralizing epitopes (RILAVERYLKD, ELDKWA and GPGRAFY, designated El, E2, and E3, respectively) on HIV-1 envelope proteins, three epitope-peptides ((E1)2: C-(RILAVERYLKDG)2; (E2)4: C-(ELDKWAG)4; and (E3)2:C-(GPGRAFY)2) were synthesized and then conjugated with carrier protein keyhole limpet hemocyanin (KLH) or bovine serum albumin (BSA), and used for immunizing rabbits. After the vaccine course, the triple combination of epitope-vaccines induced high levels of predefined multi-epitope-specific antibodies. An immunoblotting-analysis demonstrated that the antibodies could recognize the native epitopes on both gp41 protein and V3 loop peptide. Furthermore, we compared the immune responses of three doses of epitope-peptides in the candidate epitope-vaccine. Strong antibody responses to three epitopes were observed in a dose dependent manner, with increasing dose raising the immune response. This result indicated that immunotolerance did not occur using an epitope vaccine dose of 80 ~tg. Thus, our results demonstrate that epitope-vaccines in combination can synchronously induce high levels of antibodies with predefined multi-epitope-specificity against HIV-1, and may be used to develop effective vaccines against HIV as a new strategy.  相似文献   
10.
介绍了1种新型的基于条形码技术的学生考勤系统,重点阐述了单片机与条形码扫描器的硬件接口设计和软件编程,同时对条形码数据的显示和无线传送进行了简要的叙述.  相似文献   
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