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Evidence from systems as diverse as mollusks, insects and mammals has revealed that adenylyl cyclase, cyclic adenosine 3′,5′-monophosphate
(cAMP) cascade, cAMP-dependent protein kinases and their substrates are required for the cellular events underlying the short-term
and long-term forms of memory. In Aplysia and Drosophila models, the coincident activation of independent paths converge to produce a synergistic activation of Ca2+/calmodulin-stimulable adenylyl cyclase, thereby enhancing the cAMP level that appears as the primary mediator of downstream
events that strengthen enduring memory. In mammals, in which long-term memories require hippocampal function, our understanding
of the role of adenylyl cyclases is still fragmentary. Of the differently regulated isoforms present in the hippocampus, the
susceptibility of type 1 and type 8 to stimulation by the complex Ca2+/calmodulin and their expression in the hippocampus suggest a role for these two isoforms as a molecular coincidence device
for hippocampus-related memory function. Here, we review the key features of Ca2+/calmodulin stimulable adenylyl cyclases, as well as the involvement of cAMP-regulated signaling pathway in the processes
of learning and memory. 相似文献
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The value of data 总被引:1,自引:0,他引:1
Mons B van Haagen H Chichester C Hoen PB den Dunnen JT van Ommen G van Mulligen E Singh B Hooft R Roos M Hammond J Kiesel B Giardine B Velterop J Groth P Schultes E 《Nature genetics》2011,43(4):281-283
Data citation and the derivation of semantic constructs directly from datasets have now both found their place in scientific communication. The social challenge facing us is to maintain the value of traditional narrative publications and their relationship to the datasets they report upon while at the same time developing appropriate metrics for citation of data and data constructs. 相似文献
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The Choice of a Forecasting Model 总被引:1,自引:0,他引:1
G.Libert 《系统科学与系统工程学报(英文版)》1992,(1)
In this article, several criteria for forecasting model selection are proposed, and some empirical comparison results are given. 相似文献
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