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Sylvia E. Le Dévédec Kuan Yan Hans de Bont Veerander Ghotra Hoa Truong Erik H. Danen Fons Verbeek Bob van de Water 《Cellular and molecular life sciences : CMLS》2010,67(19):3219-3240
Cell migration is essential in a number of processes, including wound healing, angiogenesis and cancer metastasis. Especially,
invasion of cancer cells in the surrounding tissue is a crucial step that requires increased cell motility. Cell migration
is a well-orchestrated process that involves the continuous formation and disassembly of matrix adhesions. Those structural
anchor points interact with the extra-cellular matrix and also participate in adhesion-dependent signalling. Although these
processes are essential for cancer metastasis, little is known about the molecular mechanisms that regulate adhesion dynamics
during tumour cell migration. In this review, we provide an overview of recent advanced imaging strategies together with quantitative
image analysis that can be implemented to understand the dynamics of matrix adhesions and its molecular components in relation
to tumour cell migration. This dynamic cell imaging together with multiparametric image analysis will help in understanding
the molecular mechanisms that define cancer cell migration. 相似文献
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