基于多分片贝叶斯网络的多Agent系统模型表示

多Agent系统模型表示是系统实现推理、学习、自组织和Agent间通信的基础。由于多Agent系统结点较多的特性, 一般用单个贝叶斯网络作为模型表示是不现实的。本文提出用多分片的贝叶斯网络作为多Agent系统的表示语言,并详细讨论了将多分片贝叶斯网络转化为具有良好推理计算特性的联合树扩展形式的连接联合森林的具体过程。     

几种混沌布谷鸟搜索算法的优化性能比较与仿真

针对布谷鸟搜索迭代后期收敛速度慢和搜索精度不高的不足,通过将混沌优化方法嵌入到布谷鸟搜索中构建混沌布谷鸟搜索算法。新算法利用混沌序列的随机性和遍历性来改善布谷鸟搜索的优化性能。基准测试函数集的测试结果显示新算法在收敛速度和计算精度方面都得以提高。最后将所构建的算法应用到PID参数整定问题上,对比实验结果表明改进算法是可行性和有效性的。     

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.     

软件系统设计中的模块化思想和技术

本文回顾了设计大型数据处理系统中广泛应用的结构化设计(SD)方法、结构化分析(SA)及结构化程序设计(SP),阐明控制问题复杂性的抽象和分解思想、模块特性、划分模块的原则和评价模块质量标准及模块独立性概念。     

Lipogenesis in rats adapted to intermittent starvation or continuous underfeeding

Zusammenfassung Albinoratten, bei denen zwischen die Fütterungstage 1–2tägige Hungerperioden eingesetzt wurden, zeigten nach 3 Wochen eine wesentlich erhöhte Inkorporation von 1-C¹⁴-Acetat in die Fettsäuren der Leberschnitte. Selbst bei Herabsetzung der Kalorienzufuhr um ca. 50% stieg hier, im Gegensatz zu kontinuierlich unterernährten Tieren, der prozentuale Körperfettgehalt. Die Resultate sprechen für eine Steigerung der Lipogenese.     

Cytochrome oxidase activity in skeletal muscle and the diaphragm of intermittently starving rats

Zusammenfassung Es wurde die Aktivität der Cytochromoxydase von Skelettmuskulatur und Zwerchfell intermittierend hungernder Ratten und bei chronisch durch verminderte Tagesrationen unterernährten Ratten untersucht. Bei den an intermittierendes Hungern adaptierten Ratten war die auf den Gewebestickstoff bezogene Aktivität dieses Enzyms um 80–100% erhöht im Vergleich zu denad libitum gefütterten Kontrolltieren. Bei den einer gewöhnlichen kalorischen Unterernährung ausgesetzten Tieren war die Cytochromoxydaseaktivität praktisch dieselbe wie die der Kontrolltiere.     

A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants

The phytohormone auxin acts as a prominent signal, providing, by its local accumulation or depletion in selected cells, a spatial and temporal reference for changes in the developmental program. The distribution of auxin depends on both auxin metabolism (biosynthesis, conjugation and degradation) and cellular auxin transport. We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required for auxin-dependent regulation of plant growth by determining the cellular sensitivity to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signalling. PILS activity affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via intracellular accumulation and metabolism. Our findings reveal that the transport machinery to compartmentalize auxin within the cell is of an unexpected molecular complexity and demonstrate this compartmentalization to be functionally important for a number of developmental processes.     

TUSC3: functional duality of a cancer gene

Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum.