吸附法治理汞废气的机理研究

该文对载银活性炭吸附汞蒸气的机理进行了探讨 ,通过电子探针和扫描电镜对载银活性炭及被汞“饱和”的载银活性炭进行微观结构分析 ,结果显示 ,银在活性炭中主要分布于活性炭的凸面处 ,汞只在有银存在的地方出现 ,表明普通活性炭不具备吸附汞的能力 ,载银活性炭吸附汞属于以银为核心的多分子物理吸附 ,工业上的“饱和”载银活性炭仍具有一定的吸附汞蒸气的能力 ,为交替式吸附床的结构设计提供了技术依据 .     

一种基于最小熵准则的SAR图像自聚焦算法

研究了一种新颖的SAR图像自聚焦算法。该方法从复图像域出发 ,利用最小熵准则盲解卷积原理 ,通过多维搜索完成相位误差校正。同相位梯度自聚焦算法相比 ,最小熵算法无需在图像域分离出强点目标 ,因而特别适用于无任何明显特征的图像。仿真及实测数据处理结果证明了该方法的有效性     

国有大中型工业企业技术创新问题浅析

通过对天津市国有大中型工业企业的调查，揭示了国有大中型工业企业技术创新中存在的问题，并对提高国有企业技术创新能力提出了建议。     

英语写作中的主要干扰因素——汉语词语及句法

在导致英语写作时出现言语错误的各因素中母语的影响居为首位。而汉语对英语写作的干扰中以汉语的词语及句法的干扰较为突出。应使学生主动适应英语思维,有意识地避免母语的负迁移,不断提高英语写作能力。     

Toxin bioportides: exploring toxin biological activity and multifunctionality

Toxins have been shown to have many biological functions and to constitute a rich source of drugs and biotechnological tools. We focus on toxins that not only have a specific activity, but also contain residues responsible for transmembrane penetration, which can be considered bioportides—a class of cell-penetrating peptides that are also intrinsically bioactive. Bioportides are potential tools in pharmacology and biotechnology as they help deliver substances and nanoparticles to intracellular targets. Bioportides characterized so far are peptides derived from human proteins, such as cytochrome c (CYCS), calcitonin receptor (camptide), and endothelial nitric oxide synthase (nosangiotide). However, toxins are usually disregarded as potential bioportides. In this review, we discuss the inclusion of some toxins and molecules derived thereof as a new class of bioportides based on structure activity relationship, minimization, and biological activity studies. The comparative analysis of the amino acid residue composition of toxin-derived bioportides and their short molecular variants is an innovative analytical strategy which allows us to understand natural toxin multifunctionality in vivo and plan novel pharmacological and biotechnological products. Furthermore, we discuss how many bioportide toxins have a rigid structure with amphiphilic properties important for both cell penetration and bioactivity.     

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor

The ubiquitylation of cell-cycle regulatory proteins by the large multimeric anaphase-promoting complex (APC/C) controls sister chromatid segregation and the exit from mitosis. Selection of APC/C targets is achieved through recognition of destruction motifs, predominantly the destruction (D)-box and KEN (Lys-Glu-Asn)-box. Although this process is known to involve a co-activator protein (either Cdc20 or Cdh1) together with core APC/C subunits, the structural basis for substrate recognition and ubiquitylation is not understood. Here we investigate budding yeast APC/C using single-particle electron microscopy and determine a cryo-electron microscopy map of APC/C in complex with the Cdh1 co-activator protein (APC/C(Cdh1)) bound to a D-box peptide at ～10 ? resolution. We find that a combined catalytic and substrate-recognition module is located within the central cavity of the APC/C assembled from Cdh1, Apc10--a core APC/C subunit previously implicated in substrate recognition--and the cullin domain of Apc2. Cdh1 and Apc10, identified from difference maps, create a co-receptor for the D-box following repositioning of Cdh1 towards Apc10. Using NMR spectroscopy we demonstrate specific D-box-Apc10 interactions, consistent with a role for Apc10 in directly contributing towards D-box recognition by the APC/C(Cdh1) complex. Our results rationalize the contribution of both co-activator and core APC/C subunits to D-box recognition and provide a structural framework for understanding mechanisms of substrate recognition and catalysis by the APC/C.     

A Pluto-like radius and a high albedo for the dwarf planet Eris from an occultation

The dwarf planet Eris is a trans-Neptunian object with an orbital eccentricity of 0.44, an inclination of 44 degrees and a surface composition very similar to that of Pluto. It resides at present at 95.7 astronomical units (1?AU is the Earth-Sun distance) from Earth, near its aphelion and more than three times farther than Pluto. Owing to this great distance, measuring its size or detecting a putative atmosphere is difficult. Here we report the observation of a multi-chord stellar occultation by Eris on 6 November 2010 UT. The event is consistent with a spherical shape for Eris, with radius 1,163?±?6?kilometres, density 2.52?±?0.05 grams per cm(3) and a high visible geometric albedo, Pv = 0.96(+0.09)(-0.04). No nitrogen, argon or methane atmospheres are detected with surface pressure larger than ～1?nanobar, about 10,000 times more tenuous than Pluto's present atmosphere. As Pluto's radius is estimated to be between 1,150 and 1,200 kilometres, Eris appears as a Pluto twin, with a bright surface possibly caused by a collapsed atmosphere, owing to its cold environment. We anticipate that this atmosphere may periodically sublimate as Eris approaches its perihelion, at 37.8 astronomical units from the Sun.     

飞龙掌血水提物的扩血管作用及原理初探

飞龙掌血的水提物飞龙一号(F01)给小鼠腹腔注射,其 LD_(50)=3.70g/kg。F01(80mg/kg)对麻醉 S.D.大鼠有明显降血压作用,伴有心率加快。该作用无快速耐受性,且不被 H_1及 H_2组胺受体、M 胆碱受体及β肾上腺素受体之阻断剂取消。对于离体 S.D.大鼠尾动脉螺旋条,F01(0.3至3mg/ml)可使由 KCl(60mmol/L)、NE(0.1μmol/L)或 AVP(0.01μmol/L)刺激而收缩的组织明显舒张。KCI(80mmol/L)增加血管平滑肌组织对钙的撮取,这可以通过测定组织中未被镧置换的低亲和力同位素~(45)Ca 的含量来确定。F01(0.06至4mg/ml)可显著降低这种钙摄取的增加。上述结果表明,F01具有直接扩张血管作用,此种作用与抑制钙内流有关。     

民办二级学院实行助学贷款的现状及对策

随着高等教育收费制度改革力度的加大，家庭经济困难的学生化比例日增，特别是在浙江省的民办二级学院中，这一现象更为明显。国家助学贷款政策的出台，有效地解决了部分经济困难家庭孩子上大学的问题。但由于宁波科技学院2001年才实施这项利国利民的政策，并且在实际实施过程中有一定难度。为此文章针对民办二级学院中实施国家助学贷款的现状进行了分析研究，提出了相应对策，力求把助学贷款工作做得更好。