排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Yauch RL Gould SE Scales SJ Tang T Tian H Ahn CP Marshall D Fu L Januario T Kallop D Nannini-Pepe M Kotkow K Marsters JC Rubin LL de Sauvage FJ 《Nature》2008,455(7211):406-410
Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated with tumorigenesis in a number of human tissues. Here we show that, although previous reports have described a cell-autonomous role for Hh signalling in these tumours, Hh ligands fail to activate signalling in tumour epithelial cells. In contrast, our data support ligand-dependent activation of the Hh pathway in the stromal microenvironment. Specific inhibition of Hh signalling using small molecule inhibitors, a neutralizing anti-Hh antibody or genetic deletion of smoothened (Smo) in the mouse stroma results in growth inhibition in xenograft tumour models. Taken together, these studies demonstrate a paracrine requirement for Hh ligand signalling in the tumorigenesis of Hh-expressing cancers and have important implications for the development of Hh pathway antagonists in cancer. 相似文献
1